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Researchers have suspected retroviruses to play a role in amyotrophic lateral sclerosis (ALS) since the 1960s, when poliomyelitis was proposed to contribute to progression of the disease...
A new double-transgenic mouse may provide a good model for Lewy-body diseases and offer insight into mechanisms that underlie Alzheimer's and Parkinson's disease...
Spinocerebellar ataxia type 7 (SCA7), which causes retinal cone-rod degeneration and eventual blindness, can be traced to the expansion of a CAG trinucloetide repeat—from 10 to as many as 250 triplets—in the SCA7 gene...
Two very different reports suggest that testosterone may be important in protecting neurons from Aβ, the peptide suspected of killing neurons in Alzheimer's disease...
Tomorrow's Nature magazine carries an article on head trauma that could inform parts of Alzheimer's research, as well. Esther Shohami at Hebrew University's Medical Faculty in Jerusalem, and colleagues there, report that an endogenous cannabinoid plays a role...
Most cases of amyotrophic lateral sclerosis (ALS) have no familial history that could help researchers home in on genetic causes. About 10 percent of cases are inherited, from which five potential ALS genes have been mapped to independent chromosome regions...
One of the hallmarks of sporadic Parkinson's disease (PD) are Lewy bodies (LB), neuronal cytoplasmic inclusions that contain ubiquitinated proteins. Recently researchers have focused on two key LB components, the 16 kDa α-synuclein, and the ubiquitin-ligase parkin...
The deposition of Aβ has long been implicated in the cellular damage and subsequent cognitive dysfunction of Alzheimer's disease, but the mechanism for this remains unclear...
In tomorrow's Science, Bjorn Falkenburger, Karen Barstow, and Isabelle Mintz of Boston University Medical Center demonstrate a novel mechanism for dopamine release in the substantia nigra (SN)...
The Biology of α-Synuclein and Lewy body Disease Workshop Meeting Cosponsored by NIA and NINDS, Bethesda, Maryland, July 16-17, 2001...
In a feat of miniaturization, researchers have engineered a fluorescence microscope that is three inches long, weighs less than an ounce, and sits perched on a rat's head...
Mutations in the presenilin 1 gene (PS1) are responsible for most cases of early-onset familial Alzheimer's disease (FAD). These mutations are accompanied by an increase in β-amyloid peptides.
The National Institute of Aging has awarded $54M over five years, one of its largest-ever grants, to the Alzheimer's Disease Cooperative Study (ADCS). Directed by Leon Thal at the University of California, San Diego, this consortium of centers...
Investigators working to detect subtle changes in cognitive ability form part of the ongoing effort to develop ways of identifying people who will go on to develop AD in the future...
A cholesterol-modifying enzyme not previously implicated in Alzheimer's disease modifies production of the pathogenic Aβ peptide, report researchers led by Dora Kovacs at Massachusetts General Hospital...
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