Muscle Therapy Pumps Up ALS Mice, But No Survival Benefit
Keeping muscles strong and active in a mouse model of ALS allows the animals to perform better in the face of dwindling motor neuron input, but ultimately cannot slow their demise...
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Viral Transgenic Techniques Pay Off In Parkinson's Models
The introduction of mutant, disease-causing genes into the germline of rodents and other animals has been a great boost to neurodegenerative disease research, but there are some limitations to the method...
Neurogenesis Not Needed for Environmental Enrichment Effects
Happy mice, raised in cages filled with toys and exercise wheels, are better learners and show...
Amyloid-β—Turning Neurogenesis Into Neurogenocide?
The oldest and the youngest people are often the most vulnerable to disease. The same might be true for cells...
PINK Mutations Perturb Kinase Activity, Protein Stability in Parkinson Disease
Cases of inherited Parkinson disease, while rare, have been eagerly studied for clues to causes of the far more prevalent sporadic form of the disease. So far...
How Does Aβ Do Harm? New Clues on Insulin Signaling, Spines, Inflammation
The amyloid hypothesis of Alzheimer disease, at its simplest...
PET Probe Lights Up MCI, AD
A new study in yesterday’s New England Journal of Medicine shows that PET imaging using the amyloid-binding agent FDDNP can...
Mediterranean Diet Slims Down Risk of AD
For those of us tinkering with diet to achieve better health and stave off Alzheimer disease...
New Microarray Data Offer Grist for AD Hypothesizing Mills
Check out the newest gene microarray results in the Alzheimer's brain, and see if they give a lift to some of our favorite hypotheses and molecular suspects...
Reelin, Aβ, α7 Play Yin and Yang Around NMDA Receptors
Proposed causes of Alzheimer disease may abound in the scientific literature, but many focus on a common endpoint: sputtering synapses that spell death for neurons...
Dietary Intake: New Results to Ponder on Vitamin A, Folate
Papers in the current issue of the Journal of Neuroscience will help to refocus attention on two vitamins and their relation to AD...
Synaptic Zinc Fingered As Critical In Plaque Formation
For some time, in vitro and human research has indicated that heavy metals such as zinc, copper, or iron, are critical for the aggregation of Aβ into plaques...
Circuit Menders? Neurogenesis, Stem Cells Show Potential
Scientists hold out hope that failing neural circuits may be revived with home-grown nerve cells or with functional neurons raised externally from embryonic stem cells...
First Trial of Fish Fats Shows Promise for Early AD
The results of the first randomized, double-blind, placebo-controlled clinical trial of omega-3 fatty acid supplements for the treatment of Alzheimer disease show...
"Cat"egorical Evidence for Presenilin's Proteolytic Role?
A paper in the current PNAS is advancing the controversy over the identity of the catalytic subunit of γ-secretase, the protease responsible for the cleavage of AβPP...
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