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One of the most coveted achievements AD researchers are striving for these days is to develop a biomarker that could, simply and inexpensively, detect if a person has early Alzheimer's disease...
For years, scientists have tried to create transgenic mice that form neurofibrillary tangles, one of the two pathological hallmarks of Alzheimer's disease. All attempts failed until last year...
In a preliminary but tantalizing finding, Chris Conrad and coworkers reported today that they have found a novel, small gene in an intron of the tau gene, and that this new gene has a single-nucleotide polymorphism...
A bold, but also much-criticized, experimental therapy for Parkinson's disease involves injecting dopaminergic, human embryonic neurons into a dopamine-depleted brain area of patients...
If you thought Parkinson's disease is simply a motor disorder, think again. In recent years, researchers have increasingly realized that the disease has a cognitive component as well...
The β-secretase enzyme BACE1 become an instant favorite among researchers interested in developing small-molecule drugs against Alzheimer's disease...
There are two principal ways by which the Aβ accumulation seen in the brains of people with AD can occur. One—overproduction by β- and γ-secretases...
On this second day of the conference, scientists gave an update on the current status of Aβ vaccination. Since researchers at Elan Pharmaceuticals in 1999 first demonstrated the basic principle to immunize...
Both the protein α-synuclein, one of the major components of Lewy bodies, and the neurotransmitter dopamine have come under scrutiny as potential mediators of the neuronal loss in the substantia nigra that occurs in Parkinson's disease...
A study in yesterday's Neuron suggests that Alzheimer's disease might be linked to a disruption of protein transport machinery in neurons...
If anti-inflammatory drugs are, in fact, helping some patients counteract the neurodegeneration of Alzheimer's disease, the benefit may not come from the most obvious effects of those drugs...
Cholesterol and apolipoproteins in Alzheimer's disease have become a rapidly developing—and sometimes confusing—area of investigation, but most of it suggests that lowering cholesterol might slow disease progression...
Numerous studies have shown that positron emission tomography (PET) can reveal small metabolic changes in the brains of patients with neurodegenerative disorders, particularly Alzheimer's disease...
In India, the prevalence of Alzheimer's disease among 70- to 79-year-olds is 4.4-fold less than that of the United States. Could they have one of the curry spices to thank for that?...
Estrogen influences a seemingly endless list of physiological processes, among them blood circulation. Indeed, enhanced blood flow to critical areas of the brain is one candidate hypothesis for why estrogen replacement therapy appears to protect women against Alzheimer's disease...
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