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Dr. Samuel Gandy of Thomas Jefferson Medical School began his presentation by stating that since 1990, 14 of 15 epidemiological studies reported that hormone replacement therapy (HRT) reduced the relative risk of AD in postmenopausal women by about 50 percent...
Virginia M.-Y. Lee, University of Pennsylvania School of Medicine, summarized studies conducted by investigators in CNDR in collaboration with the Kung lAβ at Penn that seek to identify new therapies for AD...
Dr. Citron began his presentation by emphasizing that the cerebral deposition of Aβ is an early and critical feature of AD, and that Aβ is released from APP by the sequential action of two proteases, β-secretase and γ-secretase...
Yue-Ming Li, Merck and Company, began his presentation by reviewing the known biology of γ-secretase, a membrane-bound protease that cleaves within the transmembrane region of APP...
Dr. Sangram Sisodia provided a summary and critique of the foregoing scientific presentations wherein he outlined the strengths and weaknesses of each of the approaches discussed at the symposium...
The anatomical distribution of amyloid plaques in the Alzheimer's brain is well documented but poorly understood. Why do plaques litter the hippocampus but are barely seen in the cerebellum—or the liver, for that matter?...
With specific and truly effective treatments for Alzheimer's still years away, non-steroidal anti-inflammatory drugs (NSAIDs) today are among the most promising treatments to delay the onset of Alzheimer's disease...
Two papers published this week offer data that might further the search for therapies in neurodegenerative disease, particularly in Parkinson's...
It has been known since Waller's description in 1850 that axons of damaged neurons degenerate on the distal side of the lesion. Wlds mice exhibit slow Wallerian degeneration, but while they are known to harbor an 85 kb tandem triplication...
Researchers from Bart de Strooper's lab at the Flanders Interuniversity Institute for Biotechnology, reported in the 20 November Neuron that telencephalin (TLN), a member of the intercellular adhesion molecule (ICAM) family, binds to presenilins 1 and 2...
Post-Conference News: Oligomers, Protofibrils, and Fibrils—They Are All Bad Post-Conference News: Fly-Fishing for γ-Secretase Function and Substrates Society for Neuroscience Annual Meeting 2001
A number of presentations at this year's Society for Neuroscience meeting provided new insight into the biology of presenilin. First, about its function. Deletion of the notch receptor in Drosophila produces a characteristic, hypomorphic phenotype...
Extensive data supporting a central role for Aβ in the genesis of Alzheimer's disease notwithstanding, the amyloid hypothesis has its weaknesses...
The debate over the etiology of Parkinson's disease (PD) has been spurred by an article in the November 14 Journal of the American Medical Association, in which the authors contend that genetics, not just environmental factors...
RNA profiling is increasingly being used in the study of Alzheimer's disease, but interpreting the pretty microarray patterns can be difficult. To name but one problem, individual neurons vary greatly in their degree of pathology...
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