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The question of how neurofibrillary tangles (NFTs) contribute to the profound loss of neurons in Alzheimer's disease remains unsettled in part because of a dearth of suitable animal models...
In 1999, Warrick et al. showed that the molecular chaperone Hsp70 could suppress neurodegeneration mediated by polyQ expansions in a protein associated with spinocerebellar ataxia...
Just in time to ponder this weighty question comes a short communication in tomorrow's Nature. Martin Carrier and colleagues at the William Harvey Research Institute in London report that polyphenols in red wines potently inhibit expression of the vasoconstrictor peptide endothelin-1...
The Science Fiction channel occasionally runs a marathon of "Twilight Zone:" Back-to-back episodes all day long, each one related to the other through novel scripts with interesting ideas that border on fantasy...
A study of the elderly in Sweden provides more evidence that people with a higher level of education are less likely to be diagnosed with Alzheimer's disease or other dementias...
In last Friday's Nature, Lawrence Goldstein of the University of California, San Diego, further advanced his claim that the amyloid-β precursor protein (AβPP) mediates fast, anterograde axonal transport by binding to the motor protein kinesin-1...
CNDR 2nd Annual Retreat: Welcome and Introduction CNDR 2nd Annual Retreat: Amyloid-binding Ligands as AD Therapies CNDR 2nd Annual Retreat: Gonadal Hormones Control β-Amyloid in Vivo CNDR 2nd Annual Retreat: Metal Complexing Agents as Therapies for AD CND
The discovery of newly born neurons in the adult primate neocortex caused a great stir two years ago, opening, as it seemed, one of the most promising avenues of research into replacing neurons destroyed by neurodegenerative disease...
According to Ashley Bush of Harvard Medical School, Aβ is rapidly precipitated by Zn2+ at low physiological concentrations, and Cu2+ and Fe3+ also induce Aβ aggregation...
The therapeutic potential of human stem cells seems a little more realistic, thanks to results published in this month's Nature Biotechnology. Two groups have succeeded in transplanting human neural progenitors into neonatal mice...
In the last four years, cancer researchers have come to realize that the lipid phosphatase PTEN is perhaps as important a tumor suppressor as its more famous cousin p53. At the same time, other researchers are trying to harness...
The Center for Neurodegenerative Disease Research (CNDR) at the University of Pennsylvania School of Medicine organized the 2nd Annual CNDR Retreat as a one day symposium entitled "Emerging Alzheimer's Disease Therapies...
Ivan Lieberburg of Elan Corporation summarized evidence over the past 15 years supporting the role of amyloid as causal in the onset and/or progression of AD. Aβ, a 42 amino acid long peptide...
Cynthia Lemere of Harvard Medical School summarized the efforts and progress of her group to develop intranasal immunotherapy for AD in transgenic mouse models of AD-like amyloidosis by delivering the human Aβ peptides through the nasal route...
Due to the illness of Blas Frangione, New York University School of Medicine, his colleague, E. M. Sigurdsson, gave this presentation on another alternative for immunotherapy of AD. Dr. Sigurdsson reviewed recent studies of transgenic mice with AD-like brain amyloidosis...
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