Dopaminergic Neurons Conjured from Astrocytes Restore Motion
At Keystone, researchers described how directly converting astrocytes into neurons within the mouse striatum restored neuron numbers in a model of PD.
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Invading T Cells Quash Neurogenesis
Brains of old mice birth fewer neurons when T cells invade the subventricular zone. The immune cells spew inflammatory cytokines that snuff out neurogenesis.
Epilogue on Edonerpic: It Does Not Work in Alzheimer’s
Drug didn’t slow decline in a Phase 2 trial.
Deleting CD33 Benefits Mice—If Their Microglia Express TREM2
TREM2 required for reduction of plaque load in CD33 knockouts.
In PD Model, α-Synuclein Spreads from Intestine to Brain
Injecting α-synuclein fibrils into mouse gut sparked the proteopathic spread of misfolded α-synuclein into the brain, where the aggregates killed dopaminergic neurons and caused motor problems.
Herpesvirus: Trigger for Many Brain Pathologies?
At Quebec conference, researchers considered multiple aspects of herpesvirus biology that may come in to play in AD.
11th International Conference on HHV-6 and HHV-7
Going Viral: Alzheimer’s Research at Herpes Conference Herpesvirus: Trigger for Many Brain Pathologies? In light of recent work implicating human herpesviruses in AD, virologists invited Alzheimer’s researchers to join them at the 11th International Confe
New Tool Kit Helps Physicians Recognize and Manage Lewy Body Dementias
A U.K. research program developed guidelines for clinical practice. In preliminary studies, it boosted diagnosis and improved patient care.
International Lewy Body Dementia Conference
New Tool Kit Helps Physicians Recognize and Manage Lewy Body Dementias Consortia Assemble Worldwide to Take on Lewy Body Dementia Can Researchers Detect Dementia With Lewy Bodies at the Prodromal Stage? Dementia with Lewy bodies is a devastating disorder,
Consortia Assemble Worldwide to Take on Lewy Body Dementia
The field is rapidly building the infrastructure for biomarker studies and large clinical trials.
Can Researchers Detect Dementia With Lewy Bodies at the Prodromal Stage?
The field is searching for a combination of clinical features and biomarkers that will identify the disease in people with mild cognitive impairment.
Alzheimer's Association International Conference 2019
New PET Staging Scheme for Amyloid? Physical Activity May Shield the Brain from the Onslaught of Aβ Crenezumab Update: Baseline Data from Colombian Prevention Trial Colombian Cohort Delivers Data on Blood NfL Rare Luck: Two Copies of ApoE2 Shield Against
Physical Activity May Shield the Brain from the Onslaught of Aβ
Middle-aged people who exercise more are less likely to become amyloid-positive. In late life, people with brain amyloid who exercise declined more slowly and had less brain shrinkage over the following years.
DIAD: Families from Argentina, Canada, Minnesota Rally a Global Community
A brother’s survival guilt, a journalist tracing her mutation to Lebanon, a student freezing her eggs ahead of a primary prevention trial—DIAN family members are stirring their growing community to act against Alzheimer’s disease.
2019 DIAD Family Conference: Mutation, Participation, Innovation.
DIAD: Families from Argentina, Canada, Minnesota Rally a Global Community Genetics Propels DIAN Toward Therapies ASOs: Wave of the Future in Alzheimer’s Therapeutics? As DIAN Wraps Up Anti-Aβ Drug Arms, it Sprouts Tau, Primary Prevention Arms On July 13,
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