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Researchers have synthesized a series of small chemicals that could become the starting point for a drug development effort aimed at inhibiting inflammatory changes in glial cells without affecting inflammation elsewhere in the body...
More women than men have Alzheimer's disease (AD), suggesting that loss of estrogen may increase the risk for AD in postmenopausal women. Recent studies to demonstrate that estrogen protects Alzheimer's patients have had mixed results...
Amyloid (Aβ), deposited as the major component in the plaques found in Alzheimer's brains, is a product of sequential cleavage of the amyloid precursor protein...
In the upcoming print issue of the Journal of Medicinal Chemistry, Italian researchers led by Allesandro Dalpiaz are reporting initial success in using Vitamin C to ferry drugs through the blood-brain barrier...
Elan Corporation announced last Thursday that it would temporarily suspend further drug administration in the clinical phase 2A trial of its therapeutic vaccine AN-1792...
Since it became clear that Alzheimer's disease has features in common with chronic inflammation, much effort has gone into determining whether the various inflammatory response molecules are helping to protect, or to destroy, vulnerable neurons...
Huntington's disease (HD) is caused by polyglutamine (polyQ) expansion within the huntingtin protein (Htt), but the sequence of events leading to neurodegeneration remains unclear...
Low concentrations of the hormone urocortin protects cultured hippocampal neurons from a number of toxic agents, including Aβ, according to an article in the current Journal of Neuroscience...
Over the past decade, it has become clear that microorganisms are vastly more diverse and ubiquitous than our egocentric species ever thought possible. This has led some scientists to suspect that microbes may be causing human diseases...
Though considerable effort has been spent over the last few decades investigating the relationship between Alzheimer's disease and aluminum, the role of the transition metal remains controversial...
The case for using magnetic resonance imaging to monitor changes associated with memory loss or cognitive impairment was boosted by research published in last week's PNAS...
Scientists have been racing to develop simple, non-invasive, and accurate tools for the early diagnosis of Alzheimer's disease (AD). Recently, brain imaging has received a boost by the findings of Silverman et al...
Transgenic mice have become a staple in the study of basic biology and disease, including Alzheimer's. Even so, the method predominantly used today to create these animals remains technically difficult, costly, and impractical in other animal species...
P53 misregulation and cancer have become almost synonymous in the scientist's imagination. Mutations in this prominent tumor suppressor gene have been found in the majority of human cancers...
A study in last month's Neurology provides more evidence that people who engage in little leisure activity are at greater risk for developing Alzheimer's disease. The study, by Yaakov Stern et al. at Columbia University, New York, is noteworthy...
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