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Predicting who may get Alzheimer's disease still is an almost impossible exercise. Yet with several promising treatments looming on the horizon, early diagnosis is becoming increasingly desirable...
Several recent reports have tantalized us with the possibility that adult stem cells exist that can be reprogrammed to produce various tissue types, including neurons...
A report in the current issue of the Archives of Neurology suggests yet again that cholesterol has some link with Alzheimer's disease. Kristine Yaffe and colleagues at the University of California, San Francisco, and elsewhere...
Conference Coverage: IPSEN Foundation Ipsen Colloquium on Immunization against Alzheimer's and Other Neurodegenerative Diseases 2002
ARF Scientific Advisor David Holtzman, of Washington University, St. Louis, Missouri, sent us this report from the IPSEN Foundation conference "Immunization against Alzheimer's and other Neurodegenerative Diseases," held on 13 March in Paris, France...
A nonsteroidal antiinflammatory drug (NSAID) with nitric oxide-releasing capabilities dramatically reduced amyloid burden in a transgenic mouse model, according to a report in today's Journal of Neuroscience...
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease affecting motor neurons of the central nervous system. Though its biology is poorly understood, one controversial theory suggests that oxidative damage...
Anyone who has ever contemplated the devastating effects of a neurodegenerative disease like Alzheimer's disease has two disturbing questions embedded in the back of their mind—is it going to happen to me, and if so, when?...
Today's Science contains a basic-science review relevant to anyone studying plaque or tangle formation, or the unfolded protein response in Alzheimer's or Parkinson's disease...
The loss of neurons associated with such diseases as Alzheimer's and Parkinson's have long been attributed to neural degeneration. But could this degeneration actually belie underlying problems in regeneration?...
The identity of γ-secretase, the aspartyl protease responsible for snipping amyloid-β (Aβ) from β-secretase-processed amyloid precursor protein (AβPP), has remained elusive for some time...
The European Union's Committee of Proprietary Medicinal Products (CPMP) has recently recommended that the EU approve <a href="/therapeutics">memantine</a> for the treatment of moderately severe to severe Alzheimer's disease...
Even as vitamin E appears to be losing some of its memory-saving appeal, the B vitamin folate (i.e. folic acid) is becoming the nutrient <em>du jour</em>. Besides helping to prevent birth defects, it probably reduces the risk of heart disease, stroke, and some cancers...
Though the roles of the Aβ peptide and AβPP in the pathology of Alzheimer's disease have been well studied, many questions remain to be answered, not least being cause and effect—are plaques the root or the result of the problem?...
Elan Corporation and American Home Products announced today what everyone already expected...
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