In Vitro Networks from Adult Neural Stem Cells
Ever since adult neuronal stem cells were shown to exist, those interested in neurodegenerative diseases have dreamt of using them for therapies...
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Stereotactic Insertion of Antibodies Prevents Plaque Formation
Despite Elan's trials and tribulations, the show must go on, and many researchers are pursuing what they hope will be a better antibody for treatment of Alzheimer's disease...
It's All in the Dose: Protein Levels, Not Structures, May Separate Us from Chimps
The obvious differences between humans and our closest relatives, the chimpanzees, belie the fact that our genomes differ by just over one percent...
One-Shot Deal? Mice Regain Memory Day After Vaccination, Plaques Stay Put
The first clinical trial may be dead, but AD vaccination research is alive and kicking...
Earliest Amyloid Aggregates Fingered As Culprits, Disrupt Synapse Function in Rats
While the amyloid hypothesis—that aggregates of Aβ peptide are the primary pathogen in AD—drives much of Alzheimer's disease research, it remains controversial...
Medicare Coverage Extended To Alzheimer's Patients
Medicare recipients with a diagnosis of probable Alzheimer's disease can now receive reimbursement for physical and psychological therapy treatments...
Viral Transgenic Techniques Pay Off In Parkinson's Models
The introduction of mutant, disease-causing genes into the germline of rodents and other animals has been a great boost to neurodegenerative disease research, but there are some limitations to the method...
Dopamine Agonists Versus Precursors—Which are Neuroprotective?
A growing body of evidence suggests that in addition to ameliorating the symptoms of Parkinson's disease (PD), dopamine agonists or precursors may actually affect the degeneration of dopaminergic neurons...
An Alternative Way to Measure mRNA Splicing
Though the successful development of DNA chip technology has facilitated the simultaneous measurement of thousands of mRNA transcripts in a single sample, the technology is presently incapable of distinguishing between alternatively spliced transcripts...
Autoimmunity: Good or Bad for Neuroprotection?
The old dogma that the brain and the immune system don't mix is crumbling. We now know that the CNS is not entirely privileged, and that immune cells do invade it under certain conditions. This realization...
Does the Intracellular AβPP Fragment Regulate Calcium?
The similarities between the γ-secretase-mediated processing of AβPP and the Notch receptor suggest that the AβPP intracellular domain (AICD), like its Notch counterpart, could play a role in signal transduction...
Breaking the Ties that Bind—Peptide Treatments for Huntington's Disease?
Everyone agrees: from plaques to tangles, Alzheimer's to Parkinson's, insoluble protein bodies are associated with neurodegeneration. This begs the obvious question...
Another Vaccination Approach, This One Against Cholesterol
Despite the recent setbacks in Elan's clinical trials, vaccines still have enormous potential as therapeutic agents for a variety of disorders. As reported last week at the American College of Cardiology's 51st annual scientific session in Atlanta...
Tau Accused of Blocking Transport, Causing APP to Linger and Nerve Processes to Wither
Unlike AβPP, whose physiological function remains nebulous, the protein tau is widely thought to promote neurite extension by stabilizing microtubules...
Buildup of Neurofibrillary Pathology Parallels Cognitive Decline
The link between mild cognitive impairment and Alzheimer's disease pathology grows stronger with a study in this month's Annals of Neurology. Kathy Riley, David Snowdon, and William Markesbery of the University of Kentucky report a strong correlation...
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