Zapping Amyloid with SAP Inhibitors
The idea of shrinking amyloid plaques by drawing Ab out of the brain and into the circulation, where it can be destroyed, lately has gained some acceptance...
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Toward Zeptomole Proteomics in Cerebrospinal Fluid
In the post-genome era, the next big challenge lies in mapping the proteome of every cell type, a daunting task indeed. One obstacle will be to identify trace amounts of proteins in cell or tissue samples...
ARF Advisor to Receive National Medal of Science
Ann Graybiel of the Massachusetts Institute of Technology, a member of the Alzheimer Research Forum's scientific advisory board since 1999, is one of 15 scientists...
Sniff This: Therapeutic Peptides Through the Nose?
Peptides make lousy drugs, especially for the brain. When taken as a pill or by infusion, they either bounce off the blood-brain barrier, or get degraded within minutes...
Astrocytes May Hold Key to Adult Neurogenesis
The discovery that new functional neurons arise daily in adult brains has raised hopes that endogenous stem cells may be coaxed to replace neurons lost or damaged...
Synaptic Zinc Fingered As Critical In Plaque Formation
For some time, in vitro and human research has indicated that heavy metals such as zinc, copper, or iron, are critical for the aggregation of Aβ into plaques...
Transcriptional Activators Kidnapped by Huntingtin
It is well known that an expanded polyglutamine tract (polyQ) within the huntingtin (htt) protein is the root cause of Huntington's disease (HD), but just exactly how this polyQ expansion exerts its devastating effects...
Are We Humans Really That Complex? Just Look at RNA Transcription
One of the big surprises of the genome project was the final tally of how many genes it takes to make a human...
Neurodegenerative Disorders: Common Molecular Mechanisms
Ocean Waves Stimulate Brain Waves: Meeting Report from Caribbean Neurodegenerative Disorders: Common Molecular Mechanisms
Ocean Waves Stimulate Brain Waves: Meeting Report from Caribbean
Last week, 80 researchers from Caribbean nations, the U.S., and countries in Europe, the Middle East, and Asia met in balmy Montego Bay, Jamaica, for a 5-day conference...
What Makes Amyloid Sticky?
Amyloid plaques are one of the hallmarks of Alzheimer's disease and were first described almost one hundred years ago by Alois Alzheimer. Today, however, their formation is still something of a mystery...
Diagnosing the Early Stages of Alzheimer's
As a number of drug candidates to prevent, slow, or even halt Alzheimer's disease are being developed, a new urgency is driving efforts to develop tests that can diagnose the disease in its earliest stages...
Neurons and Glia Found to Die by Apoptosis in Human Herpes Encephalitis
Infection with herpes simplex virus (HSV) not only causes cerebral inflammation in people, some also believe this pathogen is a risk factor for Alzheimer's disease...
COX-2 in Neurodegeneration: Does It Wake Up a Sleeping Cell Cycle?
Cyclooxygenase (COX), the rate-limiting enzyme in prostaglandin synthesis, is well known for its role in inflammation, but less well known for its role in neurodegeneration and cell death...
Early Clinical Results of Cox 2 Inhibitor: No Pain, No Gain?
randomized trial to test the feasibility of using the COX-2 inhibitor nimesulide as a chronic treatment in Alzheimer's patients...
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