FLIP-FRAPing One’s Way Toward Polyglutamine Pathogenesis
At least nine neurodegenerative disorders—Huntington’s disease being perhaps the best known—are caused by the reiteration of glutamine-coding CAG trinucleotides in the genome...
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Another Not-Quite-Parkinson's Model
A new mouse model of Parkinson's published in the current early online edition of PNAS develops a particularly severe motor disorder similar to Parkinson's disease but, as with a similar model reported last month, no degeneration of substantia nigra neurons...
A Step Ahead With Both Adult and Embryonic Stem Cells
The current on-line edition of Nature features two reports on generating functional adult cells, including neurons, from stem cells.
"Cat"egorical Evidence for Presenilin's Proteolytic Role?
A paper in the current PNAS is advancing the controversy over the identity of the catalytic subunit of γ-secretase, the protease responsible for the cleavage of AβPP...
Presenilin—Guilty of Proteolysis by Association?
Biology rarely re-invents the wheel. That is why proponents of the idea that presenilin (PS) and the proteolytic γ-secretases are one and the same will be pleased with a paper in tomorrow's Science by Bruno Martoglio and colleagues...
Two-Photon Microscopy Spies on Single Synapses
Synapses, those miniscule voids between neurons, or neurons and muscles, are an essential part of any nervous system—without them signals traveling along axons, the action potentials, will not propagate along their intended paths...
A New CAG Repeat Model Warns: Beware The Freely Floating Abnormal Protein!
A new mouse model of a CAG repeat disorder supports the hypothesis that soluble mutant proteins might be more dangerous than aggregates in some neurodegenerative diseases...
The Limits of Compensation: Double Loss of Proteases Causes Massive Neuronal Death
Mice lacking both cathepsin B and L, two lysosomal proteases that have been implicated in the development of Alzheimer's disease, suffer a profound loss of neurons soon after birth...
Using RNAi to Silence HIV—What about Alzheimer's?
For several years scientists have been using RNA interference, commonly known as RNAi, to post-transcriptionaly silence the expression of selected proteins...
Dynamitin in Motor Neurons: Dynamite for ALS Research?
Disruption of an axonal transport system in transgenic mice leads to a late-onset, slowly progressive motor neuron disease reminiscent of human motor neuron diseases, such as ALS. A related paper shows this axonal transport system is necessary for synaptic stability in fruit flies.
Dopamine Renders α-Synuclein Toxic to Neurons
In tomorrow's Nature Medicine, Bruce Yankner at Children's Hospital in Boston offers up a partial explanation for one of the abiding questions in Parkinson's research: Why do neurons die in such a selective pattern?...
Run For Your Brain: Exercise Boosts Hippocampal Gene Expression, Neurogenesis
In a related story (see below), Carl Cotman and Nicole Berchtold of the University of California, Irvine, detail the effects of exercise on brain plasticity...
Keep It Up: Activity-Induced Neurogenesis in Hippocampus Not Just a Blip
In today's online edition of Annals of Neurology, researchers report that a form of neuroplasticity—namely the birth of new neurons in the brain's hippocampus—can be continuously stimulated by an active, challenging lifestyle throughout...
Presenting: A Not-Quite-Parkinson's Mouse Model
A transgenic mouse overexpressing a mutant human form of α-synuclein develops Lewy body inclusions that cause neurodegeneration and a severe movement disorder, according to report in yesterday's Neuron...
Wingless Pathway Helps Tauopathy Take Off
The microtubule-associated protein tau is the major component of the intracellular neurofibrillary tangles (NFT) found in patients with various neurodegenerative disorders, including Alzheimer's and frontotemporal dementia. Scientists know that hyperphosphorylation of tau is at the root of its pathology, but...
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