Double Paper Alert—A Function for BACE, a Basis for Amyloid
This week, details of findings Alzforum previously reported from meetings in St. Moritz, Switzerland, and Madrid, Spain, are published...
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FDA Approves Amyvid for Clinical Use
The Food and Drug Administration has approved Amyvid for Aβ plaque imaging in cognitively impaired patients being clinically evaluated for Alzheimer’s disease...
Cochrane Asks for Field’s Input on Draft Reporting Standards
Most researchers agree that clinical dementia papers need reporting standards, especially when it comes to diagnostic tests...
NACC News: Building a Frontotemporal Database, and More
Alzheimer’s disease research has received a huge boost in recent years through the development of large pooled datasets...
Upping Brain ApoE, Drug Treats Alzheimer's Mice
Move over, β amyloid. Here comes apolipoprotein E—target of a potential new Alzheimer’s disease therapy that looks promising in mice...
The Guardians of Forever: Forming and Keeping Memories
Researchers have shown that overexpression of the molecule protein kinase Mζ (PKMζ), can strengthen memories long after they have formed...
Phase 3 Solanezumab Trials "Fail"—Is There a Silver Lining?
Eli Lilly and Company announced today that solanezumab did not reach its primary endpoints in either of two trials in patients with mild to moderate AD...
Geneva: At Springfield Meeting, Soul-Searching About Dearth of Drugs
Last week, scientists from around the world gathered in the Swiss-French border city of Geneva...
Naproxen/Rofecoxib Trial Results Published
Both selective (COX-2 inhibitor, rofecoxib) and nonselective (COX-1/COX-2 inhibitor, naproxen) nonsteroidal antiinflammatory drugs (NSAIDs) fail to slow the cognitive decline associated with Alzheimer's disease (AD)...
Will Tau Drug Show Its True Colors in Phase 3 Trials?
A revamped version of Rember®, which presumably inhibits tau aggregation, is now heading toward Phase 3 testing...
Toxic Synuclein Corrupts Native in Wild-Type Mice
The spread of toxic α-synuclein through the brain is not just for transgenic mice anymore...
Muscle Therapy Pumps Up ALS Mice, But No Survival Benefit
Keeping muscles strong and active in a mouse model of ALS allows the animals to perform better in the face of dwindling motor neuron input, but ultimately cannot slow their demise...
Viral Transgenic Techniques Pay Off In Parkinson's Models
The introduction of mutant, disease-causing genes into the germline of rodents and other animals has been a great boost to neurodegenerative disease research, but there are some limitations to the method...
Neurogenesis Not Needed for Environmental Enrichment Effects
Happy mice, raised in cages filled with toys and exercise wheels, are better learners and show...
Amyloid-β—Turning Neurogenesis Into Neurogenocide?
The oldest and the youngest people are often the most vulnerable to disease. The same might be true for cells...
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