The Aβ peptide that circulates in the periphery is degraded not primarily by the kidney, but in the liver, scientists report at the 8th International Conference on Alzheimer’s Disease and Related Disorders in Stockholm.
Researchers in several labs are trying to discover the genes whose expression might be controlled by the C-terminal fragment of APP. The answer is not yet in, but read about some clues presented at the 8th International Conference on Alzheimer’s Disease and Related Disorders...
Is α-T catenin the elusive LOAD gene on chromosome 10? Or is it one of several genes? Read about Steve Younkin et al.'s presentation at the 8th International Conference on Alzheimer’s Disease and Related Disorders in Stockholm...
More epidemiological data is being reported at the 8th International Conference on Alzheimer’s Disease and Related Disorders in Stockholm to strengthen the association between statin use and lower risk for AD.
Tony Wyss-Coray and colleagues are reporting that disabling the complement cascade, known for its role in innate immunity, causes hippocampal neurodegeneration and exacerbates amyloid deposition. Could this be a way in which microglial activation is beneficial in AD?
Are two new proteins the missing links to understand the γ-secretase complex? Research presented today at the 8th International Conference on Alzheimer’s Disease and Related Disorders in Stockholm suggests as much. Are more components yet to be discovered?
Today at the 8th International Conference on Alzheimer’s Disease and Related Disorders, David Holtzman's group reports that the lipid-binding protein ApoJ modulates the formation of amyloid deposits and neuritic toxicity in vivo.
Brian Balin and colleagues at the Philadelphia College of Osteopathic Medicine presented data showing that chlamydia isolated from Alzheimer’s brain, cultured, and then sprayed into the noses of young wild-type BALB/c mice can cause progressive deposition of amyloid plaques...
Stockholm. Read our coverage of the 8th International Conference on Alzheimer’s Disease and Related Disorders in Stockholm, starting with this report of advances in imaging methods and a promising new live amyloid marker.
The immediate future of hormone replacement therapy in the treatment or prevention of diseases does not look promising. A large-scale, prospective study...
In a small, preliminary study, researchers have found that the Alzheimer's drug donepezil (Aricept) can slightly improve the performance of older airline pilots on a flight simulator....
The scientific program of this year’s meeting (in Palm Beach, FL) reflected the high interest of the ASN in neurodegenerative diseases in general, and in Alzheimer's disease (AD) research in particular...