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In today’s Science, researchers from the Burnham Institute, La Jolla, California, report a new pathway that can cause neuronal apoptosis, or programmed cell death—the covalent modification of extracellular matrix metalloproteinases (MMPs)....
When it comes to food and the quality of life there is a growing wealth of knowledge that suggests “less is more.” This mantra is supported by a new study associating high caloric intake with increased risk for Alzheimer’s disease (AD)....
Research reported in the online Nature Medicine reinforces the potential of adult stem cells to repair the damaged or diseased brain, but it also points out the extent to which these cells are dependent on a healthy microenvironment.
In today’s issue of the journal Cell, researchers at Columbia University, New York, report they have figured out a way to coax ES cells into becoming motor neurons, opening up some exciting new possibilities for treating a variety of diseases...
Keith Crutcher reports on the World Alzheimer Congress in Stockholm. "From the relatively crude days of CT scans to the truly impressive detail now being offered by functional MRI, this revolution in imaging technology is making it possible to study the course of AD in ways previously unimaginable...."
Keith Crucher reports from the World Alzheimer Congress: In the symposium on amyloid-lowering strategies, Dennis Dickson presented a unique and clever approach to addressing the likelihood that macrophage-mediated clearance of amyloid will be an effective strategy in humans....
A mitochondria-protecting, anti-apoptotic bile acid can reduce neurodegeneration and motor deficits in a mouse model of Huntington's disease...
This report summarizes discussions at the second workshop on Enabling Technologies for Alzheimer's Disease (AD), held in August 2002 in Bar Harbor, Maine.
A majority of investigators agree that AβPP processing, Aβgeneration, Aβ degradation, and Aβaggregation play a major role in Alzheimer's disease.
Lead discovery is hampered by the absence of good cell-based assays in which to screen libraries against AβPP secretases and other targets.
A key controversy revolved around the value of available mouse models.
Future recommendations from the Enabling Technologies for Alzheimer's Disease Workshop in Bar Harbor, Maine.
Enabling Technologies 2002 Workshop Summary Pathways and Target Discovery: Bar Harbor 2002 Lead Discovery: Bar Harbor 2002 Mouse Models: Bar Harbor 2002 Infrastructure Development: Bar Harbor 2002 Enabling Technologies for Alzheimer Disease Research: 2002
Malcolm Leissring reports on the latest data, presented at the 8th International Conference on Alzheimer’s Disease and Related Disorders in Stockholm, on the role of insulin-degrading enzyme and neprilysin in degrading Aβ peptide in vivo....
David Altshuler and colleagues at the Whitehead Institute report that only a small fraction of SNPs arise by random mutation and that most SNPs are inherited. These findings should have a profound effect on those researchers hunting for genetic clues to disease....
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