Huntingtin, BDNF, Neurodegeneration: Is Speed of the Essence?
In today's Cell, researchers report that huntingtin (htt) enhances transport of brain-derived neurotrophic factor (BDNF) along microtubules...
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Axonal Transport Not Bothered by Tau Elevation In Vivo
Elevations in tau levels, and/or changes in its cellular distribution, disrupt microtubule function and axonal transport...
Medical Foods—Fallback Option for Elusive AD Drug Status?
Defined by the FDA in 1988, medical foods are a special class of therapeutic agent that fall somewhere in between unregulated food supplements and FDA-approved drugs...
Brief: NFL Survey on Dementia Splashes Across Front Pages
Today’s news media are abuzz with reports, and the blogosphere with opinion, about a new phone survey on dementia commissioned by the National Football League...
Brain Aβ Patterns Linked to Brain Energy Metabolism
What makes some areas of the brain more vulnerable to Aβ? A pair of related papers offer a clue...
Longevity Tied to Insulin Action in Brain
The search for the fountain of youth did not end with Ponce de Leon. Rather...
San Diego: TDP-43 Targets Loom Large—But Where’s the Bull’s Eye?
If posters at the Society for Neuroscience (SfN) meeting and a recent publication are any indication, the field is poised to discover a wealth of clues to TDP-43 function...
Sirtuin Inhibitor Boosts Cognition, Reduces Phospho-tau
Scientists blocked the activity of sirtuins and found that this inhibition restored cognition in a mouse model for AD...
Paper Alert: Do Blood-Borne Factors Control Brain Aging?
Today in Nature, researchers confirm what has been playfully called the “vampire principle”...
Abnormal Mitochondrial Dynamics—Early Event in AD, PD?
Mitochondria take the stage in three recent papers...
Paper Alert—Phase 3 Tarenflurbil Data Published
Tarenflurbil, aka flurizan, a γ-secretase modulator that showed promise in early preclinical and clinical trials, failed in Phase 3...
A Better GRIP on the Aβ-Lipid Connection
In a provocative paper, researchers led by Tobias Hartmann at the Center for Molecular Biology in Heidelberg, Germany, proposed that Aβ42 promotes...
Pilot Study Shows Promise of Passive Immunotherapy
A new approach to immunotherapy for Alzheimer disease (AD) took center stage Tuesday afternoon at the American Academy of Neurology meeting in Miami...
Traveling Tau—A New Paradigm for Tau- and Other Proteinopathies?
Researchers report that from a tiny injected seed, tau pathology eventually spreads to anatomically connected areas of the mouse brain...
Place Cells: New Way to Probe Spatial Memory in AD Mice
Researchers have for the first time recorded the firing of hippocampal place cells in Alzheimer disease model mice...
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