Case Closed: Testosterone Does Not Boost Cognition
A well-controlled trials shows that a year of treatment offers no cognitive benefit for older men with low testosterone levels.
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Bizarre Twist on Amyloid Structure
Produced by the dreaded MRSA bacterium, PSMα3 is the first known example of a natural peptide that forms amyloid fibers made not of β-sheets, but of neatly stacked α-helices.
Pee P75: A Potential Biomarker of ALS Progression?
ALS patients eliminate more p75 neurotrophin receptor than do healthy controls. P75 urine levels rise as disease worsens.
Consortium to Seek Biomarkers for Vascular Cognitive Impairment
NIH funds a five-year project to validate biomarkers for clinical trials.
Clinical-Grade Stem Cells Fail to Replicate Benefit of Research Lines
Quality control issues may have scuppered clinical trials.
Mental Training Evokes Superior Memory, Transforms Brain Networks
Mnemonic training reshapes functional connectivity patterns in the brain to facilitate recall akin to that found in memory athletes.
President Proposes Massive Cut to NIH; Potential Fallout for Alzheimer’s Unclear
The proposed budget would strike a blow to biomedical research, and science in general.
ALS Dipeptides Drive Liquid-Liquid Phase Separation, Stress Granule Formation
Route to toxicity converges with RNA binding proteins in membrane-less organelles.
Number of U.K. Dementia Researchers Doubles over Six Years
A report claims that in the U.K. dementia research grew substantially since 2008, but more gains are needed to find treatments.
Tau Immunotherapy for Aβ?
Antibodies against tau lower APP expression and degrade Aβ plaques in transgenic mice.
Does Tau’s Third Repeat Propagate Misfolding in Vivo?
Although shorter tau peptides formed fibrils in a dish, the R3 domain of tau seeded aggregation in cells.
In a First, FDA Approves Deuterated Drug for Huntington’s
By virtue of its heavy hydrogen, deutetrabenazine resists metabolism by liver enzymes, allowing clinicians to better titrate the drug.
Vascular Disease in 50s Begets Brain Amyloid in 70s
Prospective study links cardiovascular risk factors to brain amyloid.
Are CSF Assays Finally Ready for Prime Time?
In the field’s march toward automated testing, scientists for the first time used biomarker cutoffs determined in one cohort to predict amyloid accumulation in a second. It worked.
ApoE and Tau: Unholy Alliance Spawns Neurodegeneration
In tauopathy mice, ApoE4 hastened neuroinflammation and neurodegeneration. No amyloid involved. (Tip: Think A1 astrocytes.)
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