Feeling Lonely: AD Pathology Gives People Sense of Disconnection
Cognitively normal people who harbor plaques in their brains are more likely to report feelings of isolation.
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Large Phase 2 Trial Starting Up in Genetic Parkinson’s Population
Sanofi Genzyme will test a compound currently in development for Gaucher’s disease in Parkinson’s patients who carry a glucocerebrosidase (GBA) mutation.
Much ‘Adu’ About a Little: Phase 1 Data Feeds the Buzz at CTAD
Biogen and Genentech rolled out more data from their Phase 1b trials, renewing hope that amyloid removal will work and shoring up dosing for Phase 3.
Tau PET in Down’s: Unique Patterns Among Alzheimer’s Types and Stages
At CTAD, tau PET data from people in different stages of various neurodegenerative diseases highlighted both commonalities and peculiarities.
Amyloid Plaques’ Hold on Aβ42 Dampens Peptide’s Daily Rhythm
Diurnal variations disappear as less Aβ42 reaches cerebrospinal fluid. Findings may improve timing of daily amyloid treatments.
2016—A Year in Research
Alzforum reviews the major newsmakers of the past 12 months.
Antibodies Co-Opt Anti-Microbial Response to Clear Intraneuronal Tau
The finding could help researchers develop safer, more effective immunotherapies, and might apply to other types of protein aggregates as well, scientists said.
Forming FUS Droplets with a Flash of Light
By fusing disordered protein regions to a plant photoreceptor, scientists study how RNA-binding proteins form liquid droplets within the cytoplasm, and what leads these structures to spawn potentially toxic aggregates.
Microglia Give Astrocytes License to Kill
Three cytokines released by activated immune cells in the brain turn astrocytes into neuron-killing machines.
Antisense Oligos Tango with Tau Transcripts to Reverse Tauopathy
Disabling human tau mRNA in mice prevents—even reverses—tau buildup, suggesting a potential treatment for a multitude of human tauopathies.
Led Astray: Pathology Tied to “Grid Cell” Malfunction in Tauopathy Model
A new mouse study correlates neurofibrillary tangles with navigation difficulties and impaired firing of “grid cells” in the entorhinal cortex.
Consensus Reached: Dieting Monkeys Survive Longer
Two parallel studies found different answers as to whether calorie-restricted macaques live longer than ones that eat their fill. A joint analysis sets the record straight.
Solanezumab: Did Aβ ‘Reflux’ From Blood Confound Target Engagement in CSF?
Convened by ARUK to learn from the antibody’s billion-dollar bust, industry and academic leaders declare insufficient CNS target engagement, say peripheral sink did not work, and brainstorm how to move forward.
ARUK Roundtable: Where Now for Alzheimer's Disease Research?
Solanezumab: Did Aβ ‘Reflux’ From Blood Confound Target Engagement in CSF? After Solanezumab: Where Should Alzheimer’s Research Go? At an expert meeting convened by Alzheimer’s Research UK, scientists from Eli Lilly shared Aβ biomarker data from the Exped
Delirium Makes its Own Mark on Cognitive Decline
The acute state of confusion not only accelerates memory loss on its own, but also worsens decline caused by other pathologies, including Alzheimer’s disease.
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