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Just where in the pathogenic process tau deals cells their death blow is a topic of much debate and research. Two studies published this week take a closer look. Brandt et al. report on the effects of a pseudohyperphosphorylated tau mutant in hippocampal slice cultures...
Papers in tomorrow’s Cell and last week's Neuron reveal that protein phosphorylation plays a key role in spinocerebellar ataxia type 1 (SCA-1), an ultimately fatal neurodegenerative disease marked by progressive loss of muscle control...
Problems with the amyloid hypothesis notwithstanding, knowing where amyloid-β (Aβ) plaques form might be key to...
British researchers report in today’s Science that they have managed to prevent and even reverse clinical manifestations of prion disease. Surprisingly, they did it not by eliminating deposits of abnormal prions, but by...
Stem cells and RNA interference offer the latest and, to some, the greatest hope for novel therapies to fight neurodegenerative diseases...
In yesterday’s Neuron, two independent laboratories report that the Histone Acetyl Transferase (HAT) activity of CREB-binding protein (CBP) is crucial for learning and memory...
If you need a reason to get off the bench and work up a sweat, consider this: Increasing physical and mental activity dramatically lowers amyloid plaque deposition in a mouse model of Alzheimer's disease...
It is touted as only the second genetic variant for late-onset Alzheimer disease...
A study we first reported from the 2004 Society for Neuroscience annual meeting in San Diego has just been published...
When it comes to cleaning house, neurons are no slouches. Considering the number of...
In the September 6 Neuron, researchers present electroencephalography (EEG) recordings...
Last Sunday, Neurochem, Inc., announced that the results of its recently completed...
With multinational cooperation, researchers have tracked down the cause of tau-negative frontotemporal dementia linked to
Ubiquitin-positive protein inclusions are a hallmark of frontotemporal dementias and other neurodegenerative diseases...
For the first time, researchers have witnessed dopaminergic neuron sprouting in a Parkinson disease (PD) patient treated with...
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