At HAI, Researchers Explore Diagnostic Potential of a Tau Tracer
AV1451 appears too weak to diagnose non-AD tauopathies.
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Bexarotene in AD—New Twist to its M.O.
Newly discovered Aβ effects of this cancer drug may be unrelated to its previously known mechanism of action.
Coming in March: First MOOC on Lesser-Known Dementia Variants
A free, open online course on rare forms of Alzheimer’s, Lewy body, and frontotemporal dementia aims to spread knowledge while harnessing social learning.
Repeat RNAs Hitchhike to the Ends of Neurons, Attacking Neurites
Some repeats seem to interfere with regulation of translation, causing dendrites to shrink.
Scientists Whip Up Neurons from T Cells in the Blood
A new procedure turns circulating immune cells into neurons. It could simplify how scientists make patient-specific disease models.
New Class of BACE Inhibitor Selectively Targets APP in Cells
Proteolysis of other substrates, including Neuregulin, proceeds apace.
Learning About ALS by Eavesdropping on Neuron-Astrocyte Chatter
Healthy neurons tell astrocytes how to act. In the case of ALS, astrocyte signals spell trouble.
Souvenaid Trial Missed Primary, Partially Met Secondary Endpoints
Results raise the tentative prospect that a medical food might have possible cognitive benefit early in disease.
A152T: A Different Kind of Tau Mutation
Studies of two new mouse models find that this mutation leads to excitotoxicity, but little protein aggregation.
International Athens/Springfield Symposium on Advances in Alzheimer Therapy, 2016
Souvenaid Trial Missed Primary, Partially Met Secondary Endpoints New Tack on Aβ Oligomer Role in Disease and Treatment The 14th International Athens/Springfield Symposium on Advances in Alzheimer Therapy was held March 9 to 12 in Athens, Greece. Research
Meta-Analysis of 21 Years of Alzheimer's Fluid Biomarker Research
Study improves confidence in three core biomarkers and five emerging markers, most in cerebrospinal fluid and one in blood.
Genetic Resilience—Can We Find Treatments for the Sick by Studying the Healthy?
Thirteen “escapees” of childhood illness offer hope of finding protective variants that may pay dividends.
NOVA Documentary Personalizes Alzheimer’s Research and Clinical Trials
A NOVA special gets up close and personal with Alzheimer’s researchers and their patients, asking if this disease can be stopped.
Antioxidant Response Might Explain Protective Tau Allele
Scientists report that the transcription factor NRF2 regulates tau expression, stimulating production of a protective isoform.
Rademakers and Traynor Share Potamkin Prize
Neurogeneticists honored for their discoveries, especially of repeat expansions that cause ALS/FTD.
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