Cancer Drug Clears Plaque, Improves Mouse Memory
An immunotherapy drug recruits immune cells to the brain, where they help clean up amyloid plaques.
ALL NEWS
6538 RESULTS
Sort By:
- Most Recent
- Most Commented
Replication a Challenge in Quest for Alzheimer’s Blood Test
Researchers failed to confirm a high-profile, previous 10-lipid panel, but remain bullish on the potential of blood-based metabolites as biomarkers.
It’s All in the Packaging: Better Delivery Renders HDAC Combo Effective in Mice
Caging an HDAC inhibitor in a lipid chelator raised plasma and brain concentrations of the drug and doubled the lifespan of a mouse model of Niemann-Pick type C disease.
Mexiletine Banishes Muscle Cramps in Phase 2 Trial of ALS
Scientists wonder if the sodium channel blocker might also slow disease progression.
Acetylated Tau Mucks Up Memories
The modified protein prevents the synaptic protein KIBRA from managing plasticity.
Microglia Prune Synapses in a Subtype of Frontotemporal Dementia
On the heels of news that microglia mediate synaptic loss in Alzheimer’s, researchers report they may do the same in a subtype of FTD caused by progranulin deficiency.
Can’t Degrade That Pesky Misfolded Protein? Push It Off the MAPS
Not exosome, not proteasome, not autophagy: Could a new pathway dubbed MAPS facilitate the spread of amyloidogenic proteins?
In First Phase 3 Trial, the Tau Drug LMTM Did Not Work. Period.
Claims of a positive effect in a small subgroup of patients are statistically meaningless, experts say.
Aggregation-Prone Gene Expression Signature Mapped in Brain
Profile matches Braak staging regions, suggesting those areas are particularly susceptible to AD pathology.
Paper Alert: Aducanumab Phase 1b Study Published
The monoclonal antibody appears to remove plaques, although the small trial could not draw conclusions about cognition.
Immune Receptor May Smuggle α-Synuclein into Neurons, Hasten Proteopathy
The LAG3 transmembrane protein latches onto fibrillar forms of the synaptic protein and ushers them into neurons. Researchers propose targeting LAG3 to slow toxic spread of misfolded forms of synuclein.
Once Again, Statins Found to Reduce Alzheimer’s Risk
Despite conflicting results in the past, a large new study analyzing multiple statins in different ethnic groups suggests a protective effect from this class of medication.
Transport Breakdown Maroons BACE1 in Synapses, Boosts Aβ
Restoring normal transport of BACE1-carrying endosomes prevents synapse loss and cognitive decline in mice.
From Garbage Disposal to Neuromodulation? Membrane Proteasomes Churn Out Stimulating Peptides
In a bizarre twist of cell biology, researchers find proteasomes in the neuronal plasma membrane. They pump signaling peptides into the extracellular space.
Next-Generation Tau PET Tracers Strut Their Stuff
Emerging data on new tau ligands raise hope of more signal, less noise, and help with a broad range of tauopathies. Read news culled from the AD/PD and HAI 2017 meetings.
Current Filters
No filters selected