‘Godfather of Tau’ Skip Binder Dies at 63
Known for his contributions to the fundamental understanding of the tau protein, Skip Binder leaves his mark on the Alzheimer's field.
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PBT2 Takes a Dive in Phase 2 Alzheimer’s Trial
IMAGINE that: Amyloid deposition shrinks in both treatment and placebo groups, dealing a blow to the anti-aggregation drug PBT2.
Could Bolstering the Retromer Thwart Alzheimer’s?
A drug candidate for Alzheimer’s aims to make cell trafficking more efficient, reduce Aβ production.
Has ApoE’s Time Come as a Therapeutic Target?
An antibody against ApoE helps clear plaques and improves cognition in AD model mice.
Some Neurons Enlist Glia to Take Care of Their Trash
Scientists report that astrocytes help neurons destroy their unwanted mitochondria.
Phosphatase Inhibitor Promotes Protein Folding, Helps ALS Mice
The same or similar molecules might treat a variety of protein-misfolding conditions.
New Role For PICALM: Flushing Aβ From the Brain
Cellular, animal, and human studies suggest that the AD risk gene PICALM escorts Aβ through the blood-brain barrier.
New Journal Guidelines Aim to Boost Transparency in Research
The Center for Open Science published eight guidelines for journals to boost transparency and reproducibility in research. Will journals implement them?
Study Suggests Respiratory Pacemaker Reduces ALS Survival
In a clinical trial, people who used the surgically implanted breathing-assist device died nearly a year sooner than those who used only an oxygen mask.
γ-Secretase Revealed in Atomic Glory
Researchers have generated the first atomic-level structure of γ-secretase. The new view revealed interactions between amino acid residues and the locations of familial Alzheimer’s disease mutations.
ALS Gene Repeats Obstruct Traffic Between Nucleus and Cytoplasm
Three studies report that the C9ORF72 expansion prevents RNAs and proteins from shuttling properly between nucleus and cytosol.
Do Sleeper Viruses Awaken in ALS?
The genetic relics of ancient, dormant retroviruses pepper the human genome. One such virus reanimates in about one-third of ALS cases.
G-Protein Receptor Knockout Rescues Several Models of Alzheimer’s
Ablating Gpr3 reduced amyloid burden and improved memory in various AD mouse models. Researchers propose using Gpr3 inhibitors to treat AD.
Does the Blood-Brain Barrier Stand Up to Alzheimer’s? Study Finds No Breach
The blood-brain barrier barred passage of antibodies in multiple mouse models of neurodegenerative disease, suggesting it holds up well in the face of disease.
New Therapeutic Idol? Silencing Ligase Prevents Aβ Deposition in Mice
Without the E3 ubiquitin ligase Idol, microglia readily gobble up ApoE and Aβ in a mouse model of Alzheimer’s disease.
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