Alzheimer’s Field Loses Fred van Leeuwen, 71
Van Leeuwen was best known for finding frameshift mutations in APP and ubiquitin B in the brains of people with tauopathies.
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Field Loses David Allsop, First to Isolate Amyloid
Both shy and funny, Allsop was a pioneer of modern Alzheimer's research.
TREM2 Variants and CSF sTREM2 Levels Differ by Race
African Americans are likelier than non-Hispanic Caucasians to carry low-expression TREM2 variants, and less likely to carry a high-expression variant. As a result, they have less soluble TREM2 in their cerebrospinal fluid.
Diabetes in Mid-Life Drives Up Dementia Risk
People who develop Type 2 diabetes before age 60 have more than double the dementia risk, and earlier dementia onset, than those without diabetes.
Does Anti-Amyloid Immunotherapy Need the Lymphatic System?
The fewer their meningeal lymphatic vessels, the slower treated mice clear plaques. Lymphatic dysfunction also drives microglial activation, hinting at a role in pathology.
MIR-NATs: Noncoding RNAs That Rein in Aggregating Proteins?
A “mammalian-wide interspersed repeat-natural antisense transcript” blocks translation of tau mRNA. Other MIR-NATS may act on α-synuclein and APP.
Private Stock—Brain Taps Skull Bone Marrow for Immune Cells
Via recently discovered channels, freshly made monocytes and B cells in the bone marrow of the skull and vertebrae travel directly into the meninges, where they stand ready to infiltrate the brain. These immune cells are distinct from their blood-borne counterparts.
Taming ApoE Via the LDL Receptor Calms Microglia, Slows Degeneration
In a tauopathy mouse model, overexpressing the receptor lowered ApoE, prevented microglial activation, and lessened neurodegeneration. LDLR—a drug target for neuroprotection?
Microglia Share Synuclein Aggregates with Each Other Via Nanotubes
When microglia get overwhelmed by α-synuclein, they pass off aggregates to unburdened neighbors. which pass fresh mitochondria back in exchange.
Aduhelm Administration Remains a Trickle, ARIA a Concern
An analysis suggests most Medicare beneficiaries have medical conditions that would disqualify them from using the new drug; this may further limit its clinical rollout.
After Eating Tangle-Tainted Neurons, Microglia Spew Tau, Lose Appetite
Microglia regurgitate tau seeds. Then they retreat into a senescent torpor. In this state, they nonetheless pump out potentially hazardous metalloproteases.
Ratio of Short to Long Aβ Peptides: Better Handle on Alzheimer's than Aβ42/40?
Low levels of Aβ37, 38, 40 reflect low processive activity of γ-secretase. They track with age at onset in people with autosomal-dominant mutations, and may track with cognitive decline in sporadic AD.
Introducing … Sir John
Well-known to the Alzheimer’s community, John Hardy is being recognized with the knighthood in the U.K’s New Year Honours.
Do a Few “Master” Sites Control Tau Hyperphosphorylation?
Phospho groups at key residues, such as threonine 181, promoted phosphorylation at multiple distant sites along the protein, suggesting a regulatory role.
Can 10,000 Steps a Day Keep Dementia at Bay?
Adults who hit this number were half as likely as their sedentary peers to develop dementia over seven years. Power walking for 30 minutes daily cut risk by 60 percent.
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