Next Up for Human Brain Imaging: Synaptic Density?
Researchers may soon add another imaging agent to their tool kit—one that tracks synapse loss.
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Is Tau Phosphorylation All Bad?
At least one phosphate tag may quell Aβ excitotoxicity.
Flashy Treatment Synchronizes Neurons, Lowers Aβ in Mice
Diminishing Alzheimer’s pathology in mice appears to be as easy as shining a light in their eyes. Could it work in people?
New MO for Purported Anti-Amyloid Drug: Shielding APP from BACE?
Imatinib, previously reported to inhibit γ-secretase, now appears to isolate APP from BACE as well.
It’s MAGIC: Yeast Mitochondria Make Cytosolic Protein Aggregates Disappear
If it works in neurons, this disposal pathway could have implications for neurodegenerative disease.
Can Immune Gene Expression Predict Pace of Motor Neuron Destruction?
Unbiased screen turns up genes expressed in immune cells, both inside and outside the CNS.
What Lies Beneath: Intracranial Probes Pick Up Hippocampal Seizures in AD
Electrodes entering the brain through a hole above the jaw detected epileptic spikes in the hippocampi of Alzheimer’s patients. Scalp recordings missed the action.
Immunotherapy for Cerebral Small Vessel Disease?
An antibody that activates Notch 3 signaling helps keep retinal blood vessels intact in a mouse model of the small vessel disease CADASIL.
Daydreaming Network Serves as Ground Zero for Aβ Deposition
A longitudinal study identified regions in the default mode network as among the first to accumulate Aβ.
Aβ, Tau Absolved of Causing Mild Cognitive Impairment in Parkinson’s
PET scans indicate no more AD pathology in PD-MCI than healthy controls, suggesting their cognitive decline results from other factors.
There’s No Tomorrow for TOMMORROW
The trial’s sponsor announced an early end to the large Alzheimer’s prevention study based on an interim futility analysis.
In Familial Alzheimer’s, Tau Creeps into Cortex as Symptoms Show
In people with an autosomal-dominant AD mutation, Aβ and tau start accumulating long before the estimated onset of symptoms.
CRISPR Screen Pulls Down Fresh Targets for C9ORF72 ALS
A CRISPR knockout screen in human cells and mouse neurons found genes that tweak C9ORF72 toxicity, zeroing in on ER stress as a potential therapeutic target.
TREM2 Binds Aβ, Reprograms Microglia to Curb Plaques
Two new papers strengthen the evidence that TREM2 protects against amyloid pathology.
Human ApoE Antibody Nips Mouse Amyloid in the Bud
This alternative approach to Aβ immunotherapy targets unlipidated, plaque-associated ApoE.
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