New Parkinson’s Gene: DJ Mutations Make Neurons Change Their Tune
In today's SciencExpress, researchers from Italy, France, and The Netherlands report that mutations in DJ-1, a protein of unknown function, can lead to Parkinson's disease...
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Amyloid-β Zaps Synapses by Downregulating Glutamate Receptors
The amyloid-β (Aβ) peptide is a destroyer of synapses, and its attack on neurotransmission is blamed for devastating...
Neurotoxic Homocysteine Metabolite Boosts Intracellular Aβ
The epidemiologic link between elevated blood homocysteine (HC) and Alzheimer disease has spurred the search for the mechanisms by which...
We Are What We Consume? Foods, Drugs Affect Amyloid, AD
A trend is afoot in Alzheimer disease research that is both potentially alarming and hopeful...
Excess α-Synuclein Sends Synapses Sputtering
Researchers propose that several-fold increases of α-synuclein can trigger a slew of pathological changes leading to synaptic dysfunction...
ADNI: One-year Data Narrow Field of MRI, FDG-PET Approaches
Alzheimer imaging aficionados gathered for a peek at the latest data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI)...
The Toxic Fold? Aβ Dodecamers, Tetramers Show Their Conformations
Amyloid-β (Aβ) peptide oligomers have come under intense scrutiny as the prime suspects in the synapse loss and neurotoxicity associated with Alzheimer disease...
Protective APP Mutation Found—Supports Amyloid Hypothesis
Does β amyloid accumulation drive Alzheimer’s disease?...
NIH Calls for More (and Different) Research on Preventive Measures
A much greater investment in AD research will be needed before scientists can draw reliable conclusions about what factors increase or decrease risk of developing AD...
ApoE4 Makes Blood Vessels Leak, Could Kick Off Brain Damage
New evidence appearing in today’s Nature implicates the ApoE4 allele, the primary genetic risk factor for late-onset AD, as a prime culprit in damaging brain blood vessels...
Presenilins and Calcium: A Lysosomal Stew With Acid Controversy
Presenilins and calcium seem to share a close connection...
Philadelphia: Can a Shrinking Brain Be Good for You?
Perhaps…yes? At first blush, this is the tentative conclusion one must draw if the results of presentations yesterday on Elan's vaccine...
Crystal Ball for AD? Studies Quantitate Risk Factors, Markers of Progression
Using data from a longitudinal study of nearly 2000 Finnish adults, researchers have devised a simple scoring scheme to judge...
ABAD, aka ERAB: Mitochondrial Miscreant Returns
The Aβ-binding alcohol dehydrogenase (ABAD) forms a complex with Aβ in mitochondria, promoting leakage of free radicals, mitochondrial dysfunction, and cell death...
Metalloproteases—A Shining Challenge to Aβ
Ridding the brain of toxic amyloid may require cutting off production of Aβ peptides, but another strategy that could work is...
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