First Whole-Genome Sequencing of PSP Nets Six New Risk Loci
ApoE2 reported as raising risk for progressive supranuclear palsy, a rare tauopathy.
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Moving Alzheimer’s Diagnosis to Primary Care Could Ease Bottlenecks
A Rand report concludes that using blood-based biomarkers and cognitive tests in primary care would halve wait times for new disease-modifying therapies.
Adieu to Aduhelm: Biogen Stops Marketing Antibody
The company announced it would halt its post-market trial and stop selling the drug; the rights to it now revert to Swiss company Neurimmune.
Posterior Cortical Atrophy Is a Form of Young-Onset Alzheimer’s
Among 1,092 people with PCA, symptoms started around age 60, and 94 percent had amyloid plaques or neurofibrillary tangles.
In Lipoparticles, ApoE Double Belt Keeps the Fat In
The α-helical chains of two ApoEs wrap around lipoprotein discs. They circle in opposite directions.
First Evidence for Transmitted Alzheimer’s Disease?
Eight adults who, as children, had received growth hormone from cadavers developed cognitive problems and/or AD-like pathology in midlife.
In FTD, TMEM106b Fibrils Tip TDP-43 Dysfunction into Overdrive
Risk variant promotes TMEM106b fibrillization; protective variant discourages it.
Brain of Woman Who Died on Leqembi Shows Worst-Case Scenario
The patient, an APOE4 homozygote with severe cerebral amyloid angiopathy, developed vascular inflammation and bleeding throughout her brain.
Rising Leqembi Prescriptions Are Straining Clinic Capacity
With several thousand people across the U.S. on the drug, wait times are long, and clinics are hiring. How to meet growing demand?
AD Blood Tests Are Here. Now, Let's Grapple With How to Use Them
Scientists around the globe are studying how best to deploy Alzheimer's plasma tests in the real world. Their focus: primary care.
Paper Alert: p-Tau217 Blood Test Predicts Plaques, Tangles Over Time
ALZpath’s assay detected an annual rise in plasma phospho-tau217 in amyloid-positive people, with the steepest increase in those who also have tangles.
Cholesterol Metabolite Ups Estrogen Signaling to Keep Females Sharp
The enzyme cholesterol 24-hydroxylase protected against cognitive decline and tau pathology—but only in females.
FDA Approves BrainSee, AI Software That Purportedly Predicts AD
The software could improve prognosis, speed referrals, for people with MCI, the developer claims.
Mouse Model LOADs on the Risk Factors
When LOAD2 mice, which carry Alzheimer’s risk variants, eat a fatty diet, their proteomes change, their neurons die, and their memories fail. All sans amyloid plaques.
Per Simoa, CSF p-tau205 Tracks with Tangles, Disease Progression
The biomarker may signal tau’s early days of entanglement, and serve as a useful disease staging indicator, according to a new immunoassay.
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