Neuroimaging Offers a CLU to AD Risk Factor’s Functional Effects
Three recent studies of healthy young adults suggest that the AD risk variant of clusterin weakens communication among brain regions involved in memory...
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DIAN Dispatch from Hawaii: Glimpse at Data, Push for Trials
Leaders of DIAN gathered to brief each other to present to some 30 pharmaceutical industry scientists the first cut of baseline data from this ongoing biomarker study...
Large Genetic Analysis Pays Off With New AD Risk Genes
Researchers have been pushing genomewide association studies as a means to find genetic variants that put people at risk for AD...
Evidence Piles Up for Presenilins’ Role in Autophagy
Faulty autophagy is linked to Alzheimer’s and other age-related diseases...
New Neuropathologic Guidelines for AD Almost Ready for Primetime
New U.S. guidelines for the neuropathologic assessment of Alzheimer’s disease (AD) and related conditions are getting close to being finalized...
Not Just “Glia”: Astrocytes Are Specialized Eating Machines, Not Oligodendrocyte Siblings
A transcriptome database comparing gene expression of cell types highly purified from fresh mouse brain is offering a trove of new information...
Research Brief: Ferreting Out the Role of Astrocytes in the Brain
Neurons may not have a monopoly on storing information in the brain...
Paris: More Trial News, Mixed at Best
With the buzz surrounding amyloid-targeting therapies, it is easy to lose sight of the fact that other treatments are being tested as well...
Sink or Swim?—New Take on Aβ Antibody’s Modus Operandi
In AD immunotherapy research, the peripheral sink hypothesis claims that certain antibodies help drain the peptide from the central nervous system...
Toronto: In Small Trial, IVIg Slows Brain Shrinkage
There may be a new reason to support your local phlebotomist—if data from an extension trial of 24 people hold up in Phase 3, that is...
eFAD Research Surprise: In Mutation Carriers, Amyloid Starts in Striatum
The striatum does not have a place of notoriety in Alzheimer disease research...
San Diego: What—3 Percent? Money Woes Trump Science at SfN
Unusually for this conference, the buzz was less about the latest hot research and more about the chilling funding scenario unfolding at the NIA...
Seeds of Destruction—Prion-like Transmission of Sporadic AD?
In Alzheimer’s and other brain diseases, normal proteins adopt strange conformations that make them clump together and cause trouble for neurons, perhaps even killing them...
Research Brief: α-synuclein Spoils the Neural Neighborhood
Aggregates of α-synuclein are the principal component of Lewy bodies, neuronal inclusions found in Parkinson and other neurodegenerative diseases...
Brain Microdialysis Reveals Tau, Synuclein Outside of Cells
In many neurodegenerative diseases, pathologic proteins present tough therapeutic targets because they are intracellular—or at least were assumed to be...
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