Common Ground: Is Aβ the Foundation for Multiple Dementias?
The majority of patients with Parkinson disease eventually develop dementia, but what pathology underlies this decline?...
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Death of the Neatnik: Neurons Perish When Trash Clutters Their Space?
Two new papers highlight the importance in AD of autophagy, a means by which cells dispose of unwanted proteins...
How Cells, and Drugs, Try to Control Glutamate in the Synapse
Once the neurotransmitter glutamate has flooded the synapse and sent its signal downstream, the cleanup crew must clear out the glutamate, or the neurons will eventually die...
Glutamate Gums Up Motor, Dopaminergic Neurons
Glutamate excitotoxicity has emerged as a favorite theory for the damage that motor neurons undergo in amyotrophic lateral sclerosis (ALS)...
Astrocytes Adjust AMPA Receptors to Protect Neurons
Behind every successful neuron, and some unsuccessful ones, there are astrocytes...
ALS GWAS Confirm Chromosome 9 Risk Factor—But What Is It?
Two genetic studies point squarely at the p arm of chromosome 9, where lurks an important risk factor for ALS...
Chromogranin B: The ApoE of ALS?
Swapping a single cytosine for a thymine in a gene involved in protein secretion more than doubles a person’s risk of amyotrophic lateral sclerosis (ALS)...
Metabolomics: The Fourth Great Ome
You could say biological researchers have been binging on omes this past decade...
Aβ the Bad Apple? Seeding and Propagating Amyloidosis
On the heels of a report that tauopathy can be spread throughout the brain by the injection of a small amount of toxic tau comes a similar paper on the propagation of (Aβ)...
Chicago: NFATs, Calcineurin—Mediators of AD, PD Pathogenesis?
Several posters beefed up the concept that signaling via calcineurin and NFATs may play a central role in neurodegenerative disease pathogenesis...
Perinatal Soup—Early Pathogen or Toxin Exposures Leave Brain Vulnerable
Scientists have little trouble accepting the idea that ontogeny is a process rich in interplay between genetic and environmental factors...
Genetics of FTD: New Gene, PGRN Variety, and a Bit of FUS
The genetics of frontotemporal dementia (FTD) just got more interesting...
Meet the First Published TDP-43 Mouse
There’s a new mouse in the lab for the study of amyotrophic lateral sclerosis (ALS)...
TDP-43 Turns Itself Off, Inclusions a False Lead
In the brain, large inclusions of proteins just look like trouble, but lately, they are starting to look less culpable...
Anti-Aβ Oligomer Headed for Phase 3 Clinical Trial
Top-line data announced this week from a Phase 2 clinical trial of the drug scyllo-inositol give cause to move to Phase 3...
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