More on Moribund Mitochondrial Respiration Prior to Plaques
Mitochondrial activation waned in brain cells a year before mice developed plaques. Inhibiting the kinase GSK3β partially restored the organelles.
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Tau Fragments in Plasma Track with Tangles, Cognitive Decline
A new immunoassay detects N-terminal fragments of tau. They predict tangle accumulation, cortical atrophy, and cognitive decline.
Different Cellular Mechanisms in Familial and Sporadic Alzheimer’s?
A single-nuclei RNA-Seq study found more autophagy and chaperone gene expression in familial AD brain, more intense microglial activation in sporadic.
From St. Louis to Beijing: AD Biomarkers Change Similarly Before Symptoms
Using different methods and studying different populations, two studies report similar trajectories of fluid and imaging biomarkers over a 20-year span of AD.
No Loitering: Pathogenic Liaisons Trap TDP-43 in the Cytoplasm
Methylated CAG-repeat RNAs and 14-3-3θ promote TDP-43 aggregation.
While a Fly Sleeps, Its Glia Burn Neuronal Lipids to Refresh the Brain
In awake fruit flies, neurons pass toxic lipids to glia for storage. When the flies sleep, glia metabolize the fat to reset for a new day.
Large Proteomic Study Flags Blood Biomarkers That Could Foretell Dementia
In more than 52,000 cognitively healthy people, elevated plasma GFAP or NfL more than doubled the risk the person would develop dementia over the next 14 years.
‛iNET’ Cultures Expose NPTX2 as TDP-43 Henchman
A new, stem-cell-based method generated neural cultures that live long enough to suffer the consequences of TDP-43 dysregulation.
In Diabetes, Tight Blood Sugar Control Staves Off Dementia
People receiving personalized Type 2 diabetes management were 28 percent less likely to develop dementia, and 15 percent less likely to get Alzheimer's.
Proteomics Uncovers Potential Markers of Early Autosomal Dominant AD
A large, unbiased study found 125 proteins in the CSF that tick up or down in early familial AD. A set of nine identified FAD mutation carriers better than did Aβ and tau.
Epigenetic Shenanigans—In AD, Chromatin Opens Up in Blood Immune Cells
In CD8+ T cells and monocytes, DNA was more accessible in people with AD and even more so in ApoE4 carriers.
New U.K. Trials Network to Accelerate Dementia Studies
£50 million in funding will expand trial access, increase recruitment, streamline study processes, and train staff over the next five years.
Under the Radar: APP Uppsala Fibrils Evade Microglia, PiB, Leqembi
In mice, these Aβ fibrils avoid riling microglia and astrocytes. They also evade both PiB and lecanemab.
Meningeal Cuffs Around Veins Form Exit and Entry Ramps to the Brain
Using live imaging in mice, scientists found that tracers and immune cells move between brain and dura through gaps in the arachnoid mater around veins.
A Biological Definition of Parkinson’s Disease: Two Proposals Pave the Way
With newly available fluid biomarkers that detect α-synuclein pathology in the brain, researchers articulate ways to classify the disease based on its biology.
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