Mitochondrial Mayhem—PGC-1α, Respiration, and Neurodegeneration
Remember when car engines were horribly inefficient and catalytic converters nonexistent? The result was...
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ApoE4 Linked to Default Network Differences in Young Adults
Whether intensely focused or thinking of nothing in particular, people carrying the ApoE4 allele show differences in brain activity at a very young age...
Keystone: Tau, Huntingtin—Do Prion-like Properties Play a Role in Disease?
Could prion-like properties of the microtubule binding protein tau explain the phenotypic diversity and the characteristic progression of different tauopathies...
Huntington Disease: Three Ways to Tackle Triplet Disorder
Huntington disease is a neurodegenerative disorder caused by the repetition of a cytosine-adenine-guanine (CAG) trinucleotide coding for the amino acid glutamine. The repeat occurs in...
The Many Misdeeds of Aβ—Seizures and Axonal Transport Interference
Amyloid-β clearly goes rogue in Alzheimer disease, but it comes in different forms and can attack cells from within and without...
Sniffer Snuffs Out Stress, or Does Aging Boil Down to Oxidation?
Evidence linking mitochondrial oxidative stress with neurodegeneration has been pouring forth lately. But news of novel mechanisms...
Twin Study Suggests Epigenetic Differences in AD
As is true with getting into college or receiving a job offer, it’s not just pedigree but also life experiences that may determine whether a person will develop Alzheimer disease...
Honolulu: Intranasal Insulin Trial Claims Promise in MCI, AD
Intranasal insulin seemed to improve certain measures of cognition and daily function, as well as biomarker profiles, in patients with MCI or early AD...
Sleep Deprivation Taxes Neurons, Racks Up Brain Aβ?
While the occasional all-nighter to cram for exams or finish a grant proposal may seem like no big deal, losing sleep could take its toll on brain health in later life...
Dynein—Mutations Put the Brakes on Aggregate Clearance
Intracellular protein aggregation is a common theme in neurodegenerative disease. The formation of aggregates is blamed on...
Can’t Close Spigot? Try Opening Drain: New Tack on Amyloid Degradation
Scientists prospecting the amyloid hypothesis for new treatment strategies have set their sights on the idea of boosting the enzymatic destruction of the Aβ peptide...
Genetic Screens Capture Clues to Pathology in Flies, Worms
With the help of simple model organisms, two research groups have come up with dozens of genes that could be tied to pathological events in two major neurodegenerative diseases...
Lou Gehrig’s Disease—On the Rise?
Amyotrophic lateral sclerosis rates may be increasing slightly, according to a paper in the April Archives of Neurology...
α-Synuclein’s Day Job: To Chaperone SNARE Complexes?
To release neurotransmitters, nerve terminals must repeatedly break down and rebuild specialized protein complexes, and the fidelity of this process may rely on α-synuclein...
PPMI: Parkinson's Field’s Answer to ADNI
One of the great challenges with developing treatments for neurodegenerative disorders stems from the capricious nature of disease progression...
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