ACAT and Mouse—Inhibiting Former Prevents AD-like Pathology in Latter
Inhibiting ACAT, a cholesterol-modifying enzyme, may prove a viable therapy for preventing or slowing the progression of Alzheimer disease...
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New Neurons in Old Brains Make New Contacts
Studies over the last few years have debunked the dogma that new neurons cannot grow in adult mammalian brains. In fact...
The Shape of Prions to Come? Conformation Contributes to Contagion
Prion amyloids and other transmissible spongiform encephalopathies are protein aggregates with a flair for self-promotion...
Tau Shows Subtle Hints of Genetic Association
For years, geneticists studying tau have been stymied by the conspicuous absence of...
Network Diagnostics: "Default-Mode" Brain Areas Identify Early AD
A loss of activity in areas of the brain that typically fire up when our brains are at rest may prove to be an accurate diagnostic marker for the earliest stages of Alzheimer's disease...
Curry Ingredient Spices Things Up by Blocking Aβ Aggregation
The curry spice curcumin is a potent antioxidant and has been investigated by Greg Cole's team at the University of California, Los Angeles, for possible protective roles in Alzheimer disease...
Neuronal Plasticity the Arbor Way—Dendritic Remodeling in the Neocortex
The word "plasticity" means different things to different people. One of its common uses refers to...
Local Control: Dendritic BC1 RNA Regulates Dopamine Receptor Levels
The brain-specific noncoding cytoplasmic RNA BC1...
Donepezil—Relief for Patients with Severe AD?
With the exception of the glutamate antagonist memantine, the only drug treatments currently approved...
Salzburg: Aβ’s N-terminal Shenanigans
The mythical Hydra was virtually indestructible. Lop off one of its many heads, and another would take its place. Chopping off the first two N-terminal amino acids of Aβ1-40/42...
Hot Stuff—PIB News From the Pacific Rim
The Pittsburgh Compound-B (PIB) ligand is one of the most promising diagnostic tools for Alzheimer disease...
CHIP Shuts Down Stress Response via Hsp70 Degradation
How a cell handles its garbage—meaning, misfolded or damaged proteins—can be a matter of life and death...
Chicago: Bapineuzumab’s Phase 2—Was the Data Better Than the Spin?
The story of how Elan/Wyeth’s antibody therapy fared at the ICAD is one of the stranger tales in AD drug development...
DC: Primate, Mouse Studies Sustain Aβ Immunotherapy Hopes
Loaded with promise and disappointment, the roller-coaster tale of Alzheimer disease vaccine development has raised hopes and dampened some...
Statins—New Data Suggest Benefits for AD/PD
Stymied by statin data? Some studies suggest...
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