AMPA Receptors: Going, Going, Gone in Aβ-exposed Synapses, PSD95 Knockouts
One of the earliest signs of amyloid-β (Aβ) toxicity is synaptic loss, and recent work from a number of labs has shown that...
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Philadelphia: All Is Not Well with the Statin Story
One of the field’s biggest hopes for a quick and easy new AD therapy received a punch in the stomach today...
Statins and AD—What Role Isoprenoids?
There has been considerable excitement generated by findings that statins, which lower plasma cholesterol, may help protect against Alzheimer disease...
AD Clinical Pipeline: Immunotherapy Woes, Dimebon Boons
Two papers in the 19 July Lancet bring both dismay and hope to the ongoing quest for more effective AD treatments...
Genetic Testing a Foggy Crystal Ball at Best?
Sequencing a person’s entire genome will foretell many diseases only marginally better than gazing into a crystal ball...
CTAD: New Data on Sola, Bapi, Spark Theragnostics Debate
The 5th Clinical Trials in Alzheimer’s Disease conference offered new data from ongoing analyses of the Phase 3 programs on solanezumab and bapineuzumab...
Early Intervention Trial Bears Little Fruit, but Sows Hope
Is the glass half empty or half full? Alzheimer disease clinicians might be asking themselves that question after seeing the long-awaited results of...
Cholinergic Transmission and Aβ: Boosting M1 Receptors Treats Model
An impressive data set that appeared yesterday in Neuron shows that a specific M1 muscarinic receptor agonist can...
Coping with Copper—Minute Amount of Metal Plagues Rabbit Brain
This week's PNAS early online edition reports that, depending on the diet, even minor amounts of copper can lead to both amyloid plaques and a memory deficit in rabbits...
Nicastrin—A DAPper Role in γ-Secretase
Though we've known for some time now that the protein nicastrin is a major player in the γ-secretase complex...
Presenilin—Guilty of Proteolysis by Association?
Biology rarely re-invents the wheel. That is why proponents of the idea that presenilin (PS) and the proteolytic γ-secretases are one and the same will be pleased with a paper in tomorrow's Science by Bruno Martoglio and colleagues...
From Protein Trafficking to Episodic Memory: Tracing BDNF Genotypes
An ambitious attempt to link cognitive tests, functional brain imaging, and cell biological assays implicates a polymorphism in brain-derived neurotrophic factor (BDNF) as the source for highly specific memory deficits...
Hormone Replacement Therapy Latest Entry to AlzRisk Database
Despite almost two decades of research, it is not yet clear how hormone replacement therapy affects a woman’s risk of getting Alzheimer’s disease...
Aβ, Shifty Drifter? Tissue Grafting Sheds Light on Plaque Formation
An article in the February 24 Nature Neuroscience online suggests that amyloid-β (Aβ), the peptide responsible for the intercellular plaques that appear in the brains of Alzheimer's patients, can freely diffuse through neural tissue, and that it plays a major role in the pathogenesis of the disease...
A PD Trifecta: Synuclein Gene Expression, Aging, and Inflammation
A trio of collaborators has unearthed an unlikely regulator of α-synuclein gene (SNCA) expression...
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