From Treadmills to Transcriptomes: Consortium Charts Molecular Responses to Exercise
First papers from MoTrPAC initiative report myriad responses to endurance training in multiple organs in rats, including the brain and heart.
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In ADAD, Plaque Removal Improves Synaptic and Inflammatory Biomarkers
In the DIAN familial AD prevention trial, plaque-busting antibody gantenerumab, but not monomer-targeting solanezumab, nudged fluid markers toward normal.
Stirred by Tau, Neurons Amp Up Lipid Droplets in Glia
Tauopathy cranks up lipid synthesis in neurons, which slip the fats to microglia. Blocking AMP kinase greases this process.
APP C-Terminal Fragments Stifle Calcium Flow from ER to Lysosomes
Amyloid precursor protein CTFs accumulate in lysosomes adjacent to endoplasmic reticulum. This disrupts calcium flow between the organelles.
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