Fast Plaque Clearance with Little ARIA? So Teases Trontinemab at AD/PD 2024
In a small dose-finding study, Roche’s new brain-shuttle-based anti-amyloid antibody mopped up nearly all plaques in three months, without triggering edema.
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Paper Alert: APOE4 Packs on Lipid Droplets in Microglia
In APOE4/4 microglia, Aβ triggers an uptick of a triglyceride synthesis enzyme. The cells then accumulate lipid droplets and release something neurotoxic.
HIV Drug Safe in Alzheimer’s Pilot Trial, Nudged Biomarkers
Lamivudine slightly improved markers of astrogliosis and amyloid pathology. The drug suppresses activity of retrotransposons that are under-methylated in AD.
Nearly Two Years After FDA Approval, Relyvrio Bombs Phase 3 for ALS
All endpoints were missed. Company to consider withdrawing the drug, as discussed during FDA Advisory Committee meeting.
Neuroprotective Extracellular Matrix Seen in C9ORF72 ALS/FTD Models
Modeling physiological dipeptide repeat expression and partial loss of normal C9ORF72 protein, new knock-in mice show a TGF-β1-driven collagen response in their spinal neurons.
Do Sleep Rhythms Create Ion Waves That Rinse the Brain?
In snoozing mice, silencing neurons dampened ion waves in the interstitial fluid and slowed the flow of solutes. Activating neurons powered CSF flow through the brain.
More on Moribund Mitochondrial Respiration Prior to Plaques
Mitochondrial activation waned in brain cells a year before mice developed plaques. Inhibiting the kinase GSK3β partially restored the organelles.
Tau Fragments in Plasma Track with Tangles, Cognitive Decline
A new immunoassay detects N-terminal fragments of tau. They predict tangle accumulation, cortical atrophy, and cognitive decline.
Different Cellular Mechanisms in Familial and Sporadic Alzheimer’s?
A single-nuclei RNA-Seq study found more autophagy and chaperone gene expression in familial AD brain, more intense microglial activation in sporadic.
From St. Louis to Beijing: AD Biomarkers Change Similarly Before Symptoms
Using different methods and studying different populations, two studies report similar trajectories of fluid and imaging biomarkers over a 20-year span of AD.
No Loitering: Pathogenic Liaisons Trap TDP-43 in the Cytoplasm
Methylated CAG-repeat RNAs and 14-3-3θ promote TDP-43 aggregation.
While a Fly Sleeps, Its Glia Burn Neuronal Lipids to Refresh the Brain
In awake fruit flies, neurons pass toxic lipids to glia for storage. When the flies sleep, glia metabolize the fat to reset for a new day.
Large Proteomic Study Flags Blood Biomarkers That Could Foretell Dementia
In more than 52,000 cognitively healthy people, elevated plasma GFAP or NfL more than doubled the risk the person would develop dementia over the next 14 years.
‛iNET’ Cultures Expose NPTX2 as TDP-43 Henchman
A new, stem-cell-based method generated neural cultures that live long enough to suffer the consequences of TDP-43 dysregulation.
In Diabetes, Tight Blood Sugar Control Staves Off Dementia
People receiving personalized Type 2 diabetes management were 28 percent less likely to develop dementia, and 15 percent less likely to get Alzheimer's.
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