Acetylation Accelerates Aggregation of 3R, but Not 4R, Tau
Acetylation of lysine residues unique to 4R tau hinders protofibril folding. The findings might explain selective 3R tau deposition in Pick’s disease.
ALL NEWS
204 RESULTS
Sort By:
- Most Recent
- Most Commented
Not So Fast—The Brain Has Three Meningeal Membranes After All
Using live imaging, electron microscopy, and gene expression studies, two groups show that a purported fourth membrane is instead the inner layer of the arachnoid mater.
Does Plaque ApoE Summon Microglia to Amyloid?
In mice, microglia that sprout vascular cell adhesion molecule 1 flock to amyloid aggregates. ApoE is required.
Spooned by a Fold: MK-6240 Nestles Within Tau Protofilament
The second-generation PET ligand snuggles into the C-shaped protofilaments of tau fibrils extracted from an AD brain sample.
Endolysosomal TMEM106b Regulates Myelin Lipid Metabolism
The transmembrane protein tempers an enzyme that destroys lipids comprising myelin. Sans TMEM106b, lipid levels drop, and the myelin may be compromised.
Missing ‘Lnc’? Long Noncoding RNAs Bind Tau, Tame Stress Granules
FTLD-causing mutations in tau turned down expression of lncRNAs including SNHG8. This goaded TIA1 to form stress granules, bringing tau along for the ride.
Meet the Two New Biomarker Candidates for Lewy Body Diseases
DOPA decarboxylase in blood or CSF, and damaged mitochondrial DNA in blood cells, separated cases from controls.
Astrocyte Receptor Suppresses Neurotoxic Lipids, Preserves Neurons
Raising TMEM164 prevents astrocytes from releasing the toxic lipids, protecting neurons in models of Alzheimer’s and Parkinson’s.
When Faced with Amyloidosis, Human Transplants Die by Necroptosis
In mice, the long noncoding RNA MEG3 mediated the death of human neurons, which accumulated tau tangles.
Sit Less, Move More to Induce Irisin and Stave Off Dementia
In people over 60, sitting for 12 hours per day increased dementia risk. An exercise-induced hormone, irisin, protects via astrocytes, at least in vitro.
CSF Proteomic Panel Better Predicts Decline Than Do Classic AD Biomarkers
A curated panel of 48 proteins foretold cognitive decline. It also illuminated biological pathways involved in Alzheimer's disease.
Could Blood Transfusions Transmit Vascular Amyloid?
A retrospective study found an increased risk of brain bleeds in people who received blood from someone else with such bleeds, hinting at a soluble agent. Aβ?
Alzheimer’s Early Detection Challenge Announced
The NIA invites scientists to submit data to create diverse, open datasets and design diagnostic algorithms for more accurate, early prediction of Alzheimer’s.
PLCγ2 Variants Toggle Microglial Plaque Compactors
In a mouse amyloidosis model, a protective variant tightened the reins on plaques and spared synapses; a risk variant did the opposite.
In Alzheimer Brain, Can Synaptic Pruning Be Good?
Provocative new data suggest that glial engulfment of synapses dampens network hyperexcitability early in disease. Key mediators: TREM2 and phosphatidylserine.
Current Filters
- Date Range : May 2023 to May 2024 x