Proteomics Uncovers Potential Markers of Early Autosomal Dominant AD
A large, unbiased study found 125 proteins in the CSF that tick up or down in early familial AD. A set of nine identified FAD mutation carriers better than did Aβ and tau.
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Epigenetic Shenanigans—In AD, Chromatin Opens Up in Blood Immune Cells
In CD8+ T cells and monocytes, DNA was more accessible in people with AD and even more so in ApoE4 carriers.
New U.K. Trials Network to Accelerate Dementia Studies
£50 million in funding will expand trial access, increase recruitment, streamline study processes, and train staff over the next five years.
Under the Radar: APP Uppsala Fibrils Evade Microglia, PiB, Leqembi
In mice, these Aβ fibrils avoid riling microglia and astrocytes. They also evade both PiB and lecanemab.
Meningeal Cuffs Around Veins Form Exit and Entry Ramps to the Brain
Using live imaging in mice, scientists found that tracers and immune cells move between brain and dura through gaps in the arachnoid mater around veins.
A Biological Definition of Parkinson’s Disease: Two Proposals Pave the Way
With newly available fluid biomarkers that detect α-synuclein pathology in the brain, researchers articulate ways to classify the disease based on its biology.
First Whole-Genome Sequencing of PSP Nets Six New Risk Loci
ApoE2 reported as raising risk for progressive supranuclear palsy, a rare tauopathy.
Moving Alzheimer’s Diagnosis to Primary Care Could Ease Bottlenecks
A Rand report concludes that using blood-based biomarkers and cognitive tests in primary care would halve wait times for new disease-modifying therapies.
Adieu to Aduhelm: Biogen Stops Marketing Antibody
The company announced it would halt its post-market trial and stop selling the drug; the rights to it now revert to Swiss company Neurimmune.
Posterior Cortical Atrophy Is a Form of Young-Onset Alzheimer’s
Among 1,092 people with PCA, symptoms started around age 60, and 94 percent had amyloid plaques or neurofibrillary tangles.
In Lipoparticles, ApoE Double Belt Keeps the Fat In
The α-helical chains of two ApoEs wrap around lipoprotein discs. They circle in opposite directions.
First Evidence for Transmitted Alzheimer’s Disease?
Eight adults who, as children, had received growth hormone from cadavers developed cognitive problems and/or AD-like pathology in midlife.
In FTD, TMEM106b Fibrils Tip TDP-43 Dysfunction into Overdrive
Risk variant promotes TMEM106b fibrillization; protective variant discourages it.
Brain of Woman Who Died on Leqembi Shows Worst-Case Scenario
The patient, an APOE4 homozygote with severe cerebral amyloid angiopathy, developed vascular inflammation and bleeding throughout her brain.
Rising Leqembi Prescriptions Are Straining Clinic Capacity
With several thousand people across the U.S. on the drug, wait times are long, and clinics are hiring. How to meet growing demand?
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