Paper Alert: p-Tau217 Blood Test Predicts Plaques, Tangles Over Time
ALZpath’s assay detected an annual rise in plasma phospho-tau217 in amyloid-positive people, with the steepest increase in those who also have tangles.
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ALZpath’s assay detected an annual rise in plasma phospho-tau217 in amyloid-positive people, with the steepest increase in those who also have tangles.
The enzyme cholesterol 24-hydroxylase protected against cognitive decline and tau pathology—but only in females.
The software could improve prognosis, speed referrals, for people with MCI, the developer claims.
When LOAD2 mice, which carry Alzheimer’s risk variants, eat a fatty diet, their proteomes change, their neurons die, and their memories fail. All sans amyloid plaques.
The biomarker may signal tau’s early days of entanglement, and serve as a useful disease staging indicator, according to a new immunoassay.
Growth-associated protein 43 in the CSF identified people who accumulated tangles fastest. These spread through connected brain regions.
Last summer saw a first: the traditional approval of a disease-modifying Alzheimer's therapy. Solid progress on biomarkers, and a flourishing of basic research, made for a good year.
Axons touch arterioles, releasing glutamate that makes smooth muscle cells relax. This increases cerebral blood flow in mice.
A U.K. Biobank analysis generated 15 risk factors for young-onset dementia. Many factors also correlated with late-onset disease.
In people on Entresto, Aβ42 and Aβ40 shot up over six months. The Aβ42/40 ratio fell by a third.
In AD brain, microglia make less of the full-length protein. Loss of INPP5D releases the brakes on inflammation, and may spur microglial phagocytosis.
A new study casts neuronal hyperexcitability as the link between Aβ aggregation in the neocortex and tau pathology in the medial temporal lobe.
Researchers wrangled gene expression, epigenetic, and spatial transcriptomic data on 32 million brain cells into the most detailed picture of the mouse brain yet.
A new method tags individual cells in a tissue slice with a DNA barcode. This allows isolated cells to be mapped to their original location.
PET tracers for the two main proteopathies of FTD, tau and TDP-43, are now in trials, while AI-enabled analysis of FDG-PET scans discriminates between diseases.