Aducanumab Approval Sparks Backlash
Industry analysts and watchdogs have heaped criticism on the FDA, while Alzheimer’s researchers remain divided over whether the decision helps or harms the field.
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DAMned to Death? Microglia May Proliferate to Senescence
In mice, disease-associated microglia proliferate so much that they become senescent. Plaques then run amok and synapses are lost.
Biogen Shelves Gosuranemab After Negative Alzheimer’s Trial
The anti-tau immunotherapy did not slow cognitive decline among people in the earliest stages of AD, nor did it evoke changes on tau-PET scans.
Sans C9ORF72, Microglia Devour More Aβ Plaques. Synapses, Too.
In the face of aging or amyloidosis, microglia lacking C9ORF72 ramped up interferon genes, accumulated lysosomes, and ate synapses.
Phase 2 Data of AADvac1 in Alzheimer’s Disease Published
The tau vaccine evoked a robust anti-tau antibody response, which curbed the rise in plasma NfL and CSF p-tau over two years. Cognitive decline continued.
Stunning Diagnostic Accuracy from a Plasma Protein Panel?
A set of 19 plasma proteins identified clinical Alzheimer’s cases with 97 percent accuracy, and it distinguished mild versus severe dementia. The panel was tested in two small cohorts.
Private Stock—Brain Taps Skull Bone Marrow for Immune Cells
Via recently discovered channels, freshly made monocytes and B cells in the bone marrow of the skull and vertebrae travel directly into the meninges, where they stand ready to infiltrate the brain. These immune cells are distinct from their blood-borne counterparts.
Neuronal Exosomes Embroiled in Controversy
The L1CAM cell adhesion marker is a widely adopted marker of neuron-derived extracellular vesicles. Except it cannot be found in those teeny packets, claims a new study.
Aducanumab Approved to Treat Alzheimer’s Disease
Biogen got the go-ahead under the FDA’s accelerated approval pathway, which requires change in a surrogate biomarker and Phase 4 studies to verify a clinical benefit.
No Breach Needed: Ultrasound Improves Memory in Mice
When pulsed through the skull, ultrasound restored synaptic signaling, neurogenesis, and memory, in old mice.
Anti-Tau Strategy PACs a Punch
Activating the G protein-coupled receptor PAC1R in the mouse brain prompts the proteasome to clear tangles.
Neurons Made from Fibroblasts Keep Imprint of Alzheimer's, Aging
Unlike iPSC-derived neurons, those created directly from fibroblasts reflect the donor's age and disease status. Epigenetic modifications appear to make the difference.
Ingested Aβ Trips Transformation in Microglia
In the plaque-ridden mouse brain, microglia that had taken up Aβ activated a unique gene-expression profile. It faded after microglia were moved to plaque-free environs.
Algorithm Bests Humans in Predicting Alzheimer’s
A person's blood phospho-tau level, combined with his or her APOE genotype and scores on executive function and memory tests, outperforms the clinician in predicting dementia within the next four years.
As Mice Age, T Cells Traipse Around Their Meninges. Mayhem Ensues
Downregulation of a chemokine receptor traps T cells in the meninges. Glymph drainage slows, amyloid burden rises.
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