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Chan et al. (Abstract 1421) used immunoblot analysis to quantitatively demonstrate that the polypeptides corresponding to AMPA (GluR2 and 3) and NMDA subfamilies of the glutamate receptors are decreased in AD brain lysates...
Mervyn Monteiro (the author of this report) and colleagues described the identification and characterization of two different proteins that interact with presenilins in the yeast-2 hybrid interaction trap (Y2H)...
Monteiro and Janicki et al. (Abstract 1057) showed by BrdU labeling of HeLa cells that overexpression of both PS1 and PS2 arrest cells in the G1 phase of the cell cycle...
June Kinoshita Interviews Bruce Yanker
Mutations in the β-amyloid precursor protein (APP), presenilin-1 and presenilin-2 cause inherited forms of Alzheimer's disease, but how do these protein interact, normally and in the disease process?...
A new study elucidates the molecular mechanisms that may explain how mutations of the tau gene give rise to frontotemporal dementia and parkinsonism (FTDP-17), an inherited disorder that is similar to Alzheimer's...
News Coverage of the 4th Hungarian Conference on AD: Hungarian Conference on Alzheimer's Disease and Related Disorders 1998
Current estimates predict that genome sequencing efforts may reveal between 3,000 and 10,000 new targets for drugs. In the December issue of Nature Biotechnology, Paul Negulescu and colleagues...
This annual meeting had significant international participation with 14 different countries being represented and, whilst comprehensive, the meeting focused on the cholinergic system, therapeutics and new findings...
The critical role of ApoE in β-amyloid deposition was demonstrated last year by Eli Lilly scientists, who crossbred APP/PS1 transgenics with an ApoE knockout and found...
The regulation of neuronal plasticity and regeneration in the CNS is an aspect of Alzheimer’s disease that often has to compete with the big stars, such as amyloid or presenilin, for attention...
Since the development of transgenic models of β-amyloid plaque formation, considerable debate has developed over the apparent paucity of neuronal cell loss found in the majority of these models...
There have been several reports over the years that the AD brain exhibits deficits in energy metabolism. In 1994, Yankner's group reported that sodium azide treatment increased...
The Athena Neuroscience PDAPP transgenic mice develop heavy Aβ deposits, particularly in the outer molecular layer (OML) of the dentate gyrus, a region that receives nerve projections from the entorhinal cortex...
The organizers of this year's special interest social on Alzheimer's disease decided to stage an awards ceremony to salute scientists who had distinguished themselves in various categories not ordinarily recognized...
