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Two research groups at Columbia University's Taub Institute have discovered new molecular partners for parkin and α-synuclein—proteins that, when mutated, cause early-onset familial forms of Parkinson's disease...
In the January 31 online PNAS, Meir Scheinfeld, Shuji Matsuda, and Luciano D'Adamio of the Albert Einstein College of Medicine in Bronx, New York, show how the carboxyl terminus of AβPP could play a significant role in gene transcription...
Neurochem announced last week that it would halt development of tramiprosate (Alzhemed)...
Like baseball coaches selecting top prospects for their team, geneticists studying Alzheimer disease face a formidable challenge...
Some NSAIDs have been shown to shift Aβ production to the shorter Aβ1-38. Now, results suggest that they do this by eliciting a conformational change in presenilin...
In the brain, too little oxygen or too much of the neurotransmitter glutamate are both bad news...
Researchers from the RIKEN Brain Science Institute in Saitoma, Japan are reporting a new MRI-based method for identifying amyloid deposits...
Researchers reported in 2012 that the cancer drug bexarotene swiftly cleared amyloid-β and restored memory in transgenic mouse models of Alzheimer's disease...
A new study adds support to the theory that a critical first step in the production of the Aβ peptide by the BACE enzyme occurs primarily in specialized, cholesterol-rich areas of the plasma membrane called "lipid rafts"...
According to the overflowing bathtub analogy, either a blocked drain (not enough clearance), an oversized faucet (too much production), or a combination, contributes to...
Although motor deficits such as a characteristically abnormal gait have been documented in Alzheimer disease (AD),...
It is a lot to ask of transplanted neuronal stem cells to...
The γ-secretase has come a long way since its original discovery as the protease responsible for the production of amyloid-β peptides during sequential cleavage of the amyloid precursor protein...
Neiman-Pick type C (NPC) disease intrigues Alzheimer's researchers for several reasons. For one thing, the neurodegenerative disorder involves...
SORLA (aka SORL1) controls the trafficking and processing of the amyloid precursor protein (APP), and thus serves as a key regulator of amyloid-β...
