Society for Neuroscience Annual Meeting: More Potential AD Gene Loci from NIMH Study
Bertram et al. (301.7), evaluated Alzheimer’s disease (AD) candidate genes and AD chromosomal regions of interest (`30 cM) from the whole genome scans available...
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Society for Neuroscience Annual Meeting: Presenilin and COX-2 Expression Induced by Oxidative Stress
The presenilin-1 and -2 (PS1, PS2) genes encode integral transmembrane proteins putatively involved in cell-cell recognition, cell-fate determination, intercellular signaling and Aβ peptide formation...
Society for Neuroscience Annual Meeting: Chromosome Missegregation Linked to PS Mutations
Presenilin-1 and -2 (PS1, PS2) gene mutations appear to cause the majority of cases of early-onset familial Alzheimer’s disease (EO-FAD). In this presentation Potter et al. (492.2) presented data...
Society for Neuroscience Annual Meeting: Role of Nicastrin-Presenilin Complexes
Presenilin-1 and -2 (PS1 and PS2) are members of a (growing) family of genes which encode polytopic integral transmembrane proteins homologous to the Notch cell surface receptors of <em>Drosophila</em>...
Immune Proteins Play Role in Brain Development and Remodeling
Two immune proteins found in the brains of mice help the brain develop and may play key roles in triggering developmental disorders like dyslexia and neurodegenerative disorders like Parkinson's disease...
Evidence of Genetic Factor in Late-Onset Parkinson's
Mutations in the genes for α-synuclein and parkin have been linked to early-onset Parkinsonism, but the role of genetics in the far more common late-onset disease has been less clear...
Score One for Nurture: Undifferentiated Adult Spinal Cells Become Neurons
Undifferentiated cells from the adult spinal cord can generate neurons when transplanted to the adult hippocampus, reveal Fred Gage and his coworkers at the Salk Institute, California, in the current issue of the Journal of Neuroscience...
Society for Neuroscience Annual Meeting: Synuclein and Parkin Roundup
The meeting in New Orleans demonstrated that the biology of α-synuclein and parkin are progressing at a rapid pace...
Reining in Macrophages
Macrophage activity is thought to play a key role in Alzheimer's and some other neurodegenerative diseases, such as ALS, as well as in autoimmune disorders. The mechanisms that regulate macrophages could...
Statins Reveal Role in Immune Response
Statins have recently appeared on the radar screen for Alzheimer's researchers because of studies by Ben Wolozin and his colleagues showing that people who take the cholesterol-lowering drugs have a significantly reduced risk of Alzheimer's disease...
A Prion Associate Is Fingered
The abnormal prion protein, but not the normal prion protein, binds with high affinity to plasminogen, a plasma component that has been linked to neurotoxicity, according to a report in the current Nature...
Society for Neuroscience Annual Meeting: Plaques Vanish Before Our Very Eyes
Last year, Brad Hyman’s group reported on their ability to image amyloid plaques in the brains of live PDAPP Tg mice. Plaques could be detected as deep as 200 microns and the same plaques could be imaged...
Society for Neuroscience Annual Meeting: The Calcium-Presenilin Connection
Several presentations focused on the role of presenilins in calcium signaling pathways. Leissring and LaFerla (Abstract 474.7) reported that cells from mutant PS1 knockin mice are deficient in capacitative calcium entry...
Society for Neuroscience Annual Meeting: Immunization of Mice and Men
What is the latest on the immunization of mice and men with Aβ? Will we be celebrating victory over Alzheimer’s disease in a few years (and looking for new jobs), or has the story been overrated?...
Soc for Neurosci Ann Mtg: β-Amyloid Triggers CD40 Expression in Microglia
CD40 is a member of the TNF receptor superfamily, which includes TNFR-1, TNFR-2, Fas, CD27, RANK, DR4 (TRAIL-R1), DR5 (TRAIL-R2), and DR6, as well as assorted decoy receptors (e.g., DcR-1/TRAIL-3)...
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