Neurogenesis and Memory
It is now generally accepted that new neurons are generated in the adult mammalian brain, but until now it has been unclear whether or not these neurons are essential for memory formation...
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Mitochondrial Exports
A British and German team has made the surprising discovery that the cell's mitochondria can export peptides into their surrounding environments. Much is known about how mitochondria import proteins, but the role of this unexpected export mechanism...
Mouse (Gene) Trap
Understanding the mechanisms regulating brain wiring has until now relied on biochemical purification approaches in vertebrates and genetic approaches in invertebrates to identify molecular clues. This week...
"Mad Yeast"?
This week Peter Chien and Jonathan Weissman of the University of California, San Francisco, explain how they used two species of yeast (and an artificial yeast prion protein to investigate how prions jump the species barrier...
Amyloid Not an Aberration?
Aggregated proteins, or amyloids, are seen in a wide variety of neurodegenerative diseases, including Alzheimer's and Creutzfeldt-Jakob (CJD) disease. Such aggregates are generally considered to be aberrant formations...
FDA Approved Reminyl® for the Treatment of Mild AD
On February 28, 2001, the U.S. Food and Drug Administration (FDA) approved Reminyl® (galantamine hydrobromide) for the treatment of mild to moderate Alzheimer's disease...
β-Secretase a Clean Therapeutic Target
The most promising target for an Alzheimer's therapy in the short term may be the enzyme β-secretase, suggest two papers in the March issue of Nature Neuroscience. Two separate groups have found that mice lacking the BACE1...
Defect in Iron Metabolism Leads to Neurodegeneration
Deleting a critical gene for iron metabolism leads to selective neurodegeneration, according to a study in this month's Nature Genetics. When researchers ablated the gene for iron regulatory protein 2 (IRP2), they produced...
Patients Sought for Nutritional Supplement Clinical
The Memory Evaluation and Treatment Service at Burke Medical Research Institute has started a therapeutic trial of a nutritional supplement...
Patients Being Recruited for Phase I Growth Factor Trial
A Phase I clinical trial of growth factor gene therapy for Alzheimer's disease is currently in progress at the University of California, San Diego...
Exelon Dose Revised
According to a "Dear Healthcare Provider" letter dated January 26 and posted this week on the Web site of the U.S. Food and Drug Administration, patients who take breaks in Exelon...
Neurogenin Suppresses Astrocyte Differentiation
Stem cell researchers know only too well that most adult neural precursor cells differentiate into astrocytes, not the coveted nerve cells. Even when stimulated by the addition of neuron-inducing growth factors...
AF102B (Cevimeline or Evoxac) Lowers CSF Aβ in Alzheimer Patients
A drug currently approved by the FDA for the treatment of dry mouth in Sjogren's syndrome (an autoimmune disease that affects excorine glands) has been shown to reduce levels of amyloid-β...
Neprilysin Steps out of the Shadows
The enzyme neprilysin—capable of degrading Aβ42 peptide—is a new player in the Alzheimer's disease mystery. Writing in Neuroscience Letters, Patrick McGeer's group at the University of British Columbia adds critical circumstantial evidence...
Study Finds Treatments for Agitation Are Inadequate
The drugs haloperidol or trazodone, or behavior management techniques (BMT), are commonly used to treat agitation in Alzheimer's patients...
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