Neurogenesis Not Needed for Environmental Enrichment Effects
Happy mice, raised in cages filled with toys and exercise wheels, are better learners and show...
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Happy mice, raised in cages filled with toys and exercise wheels, are better learners and show...
The oldest and the youngest people are often the most vulnerable to disease. The same might be true for cells...
Cases of inherited Parkinson disease, while rare, have been eagerly studied for clues to causes of the far more prevalent sporadic form of the disease. So far...
The amyloid hypothesis of Alzheimer disease, at its simplest...
A new study in yesterday’s New England Journal of Medicine shows that PET imaging using the amyloid-binding agent FDDNP can...
For those of us tinkering with diet to achieve better health and stave off Alzheimer disease...
Check out the newest gene microarray results in the Alzheimer's brain, and see if they give a lift to some of our favorite hypotheses and molecular suspects...
Proposed causes of Alzheimer disease may abound in the scientific literature, but many focus on a common endpoint: sputtering synapses that spell death for neurons...
Papers in the current issue of the Journal of Neuroscience will help to refocus attention on two vitamins and their relation to AD...
For some time, in vitro and human research has indicated that heavy metals such as zinc, copper, or iron, are critical for the aggregation of Aβ into plaques...
Scientists hold out hope that failing neural circuits may be revived with home-grown nerve cells or with functional neurons raised externally from embryonic stem cells...
The results of the first randomized, double-blind, placebo-controlled clinical trial of omega-3 fatty acid supplements for the treatment of Alzheimer disease show...
A paper in the current PNAS is advancing the controversy over the identity of the catalytic subunit of γ-secretase, the protease responsible for the cleavage of AβPP...
Disruption of an axonal transport system in transgenic mice leads to a late-onset, slowly progressive motor neuron disease reminiscent of human motor neuron diseases, such as ALS. A related paper shows this axonal transport system is necessary for synaptic stability in fruit flies.
While the hunt for new Alzheimer’s disease genes continues apace, researchers are still struggling to understand the exact <em>modus operandi</em> of the one prize they have had in hand for years: the lipid carrier protein ApoE.