Mysterious Tau Hot Spots Speckle Plasma Membrane
Super-resolution microscopy spots tiny tau clusters in live cell cultures. They come and go. Why do they form? What do they do?
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Shooting Themselves in the Foot? Microglia Block “Good” State with ApoE4
Microglial ApoE4 hobbled these cells' protective responses against Aβ and tau. In the meninges, ApoE4 made by myeloid cells slowed lymphatic drainage; at the blood-brain barrier, ApoE4 steered aging endothelial cells and pericytes toward dysregulation.
Potent TREM2 Antibody Stirs Microglia to Prune Plaques in Mice
A tetravalent IgG1 prompts TREM2 to cluster, boosting the receptor’s activation 100-fold. Treated mice had fewer plaques, better memories.
What Drives Tangles to Spread? Answers Start Rolling In
Soluble p-tau, aggregation epicenters, and gene variants emerged as potential forces that might influence how quickly tangles propagate through the brain.
AMYPAD Confirms: Amyloid PET Improves Diagnosis
In a large European study, the scans changed the diagnosis in a third of cases. They boosted the doctor's confidence in making the call, and predicted cognitive decline.
In Brain With Christchurch Mutation, More ApoE3 Means Fewer Tangles
The autopsy of a woman with a the PSEN1 Paisa mutation plus a homozygous ApoE3 variant showed an unusual distribution of tau tangles. Gene-expression studies pinpointed vulnerable neurons that were spared, and riled-up microglia in tangle-ridden zones.
Head-to-Head Study Confirms Plasma p-Tau231 Rises First in Early AD
Plasma p-tau217 and p-tau181 better track amyloid PET, tangles, and subtle cognitive decline.
A Chat Every Other Day Keeps Dementia at Bay?
The I-CONECT trial found that regular video chats boosted cognition in socially isolated older people. Even a weekly phone call enhanced their feelings of social connectedness.
Lifestyle Interventions May Fend Off Decline; Social Contact Helps
In “Maintain Your Brain,” virtual interventions gave participants a memory boost. In EXERT, cognition held steady in people who exercised. Both groups were coached.
Bringing Aduhelm—and Antibodies to Come—Into Practice
Scientists are refining safety and biomarker disclosure protocols, and are preparing to collect data on how well the new drugs work.
Could Benefit of Plaque Removal Grow in Time?
A mathematical model predicts that a tiny difference in CDR-SB after two years of treatment would grow fivefold over the next three years as progression curves separate.
Rare Variants Net New Alzheimer’s Gene, Links Between AD and CAA
Rare AD risk variants cluster within TREM2, SORL1, and the newcomer EXOC3L4. Rare mutations in ABCA7 associate with cerebral amyloid angiopathy.
Blood Tests: Charting the Path to Primary Care
Certain blood biomarker tests can tell that amyloid has built up in a person's brain and that their thinking will decline. What are the challenges ahead before these tests can be rolled out to medical care settings everywhere?
Blood Tests Go Head-to-Head in Community Cohorts
A cast of blood biomarkers for Alzheimer's has emerged from studies in research cohorts, and is now being put to the test in community cohorts. At AAIC, direct comparisons of top contenders showed that some detect amyloid and impending cognitive decline.
Alzheimer's Blood Tests Have Arrived; Road to Broad Use Still Stretches On
Finally, blood biomarkers for AD are here. Alas, the path to routine use is fraught. At AAIC, scientists discussed new guidelines, head-to-head comparisons, and logistical, technical, and ethical hurdles ahead.
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