Microglia Make Tau, Spelling Their Demise in Tauopathies
When carrying a pathogenic tau variant, microglia were bad at phagocytosis, barely made TREM2, and spat out neurotoxic proteins.
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Neuron-Glia Crosstalk Underlies Senescence, Impaired Lipid Metabolism
As flies age, mitochondrial damage in their neurons somehow ages glia, which, in turn, cause lipid droplets to pile up on other, healthy glia.
Caught in the Act: Cryo-EM Exposes γ-Secretase Catalytic Pose
The enzyme cleaves off three amino acids at a time with a twist of the substrate, and a helping hand from a β-strand.
Sans Plexin-B1, Glial Net Tightens Around Plaques
The astrocytic receptor enforces distancing among glial cells. Free from this constraint, they better contain plaques.
Does Sleep Really Speed Clearance from the Brain?
A new study challenges this idea, finding that in mice, clearance of an injected dye slowed during sleep and anesthesia.
Nuclear RNA-Binding Proteins Clump in Synucleinopathies
When the nuclear RNA-binding proteins NONO and SFPQ accumulate, adenosine-to-inosine editing of RNA runs amok. This spoils transcripts for axonal, synaptic, and mitochondrial proteins.
Neurofilament Light Clears First Hurdle as Bona Fide FTD Biomarker
FDA qualification would streamline the use of plasma NfL to select asymptomatic carriers of pathogenic frontotemporal dementia mutations for enrollment in prevention trials.
Autopsies Confirm That PI-2620 Binds 4R Tau Deposits
Scientists correlated the PET signal in PSP patients with tau deposits in postmortem brain; the signal arises from neurons and oligodendrocytes.
Could Bigger, More Complex Brains Explain Decreasing Dementia Incidence?
People born in the 1970s had 15 percent more surface area in their cortices than those born in the 1930s.
Protective ApoE Variant Quells Interferon Responses in Tauopathy
Equipped with ApoE3-Christchurch, microglia made short work of tau fibrils, and spewed fewer inflammatory cytokines.
Gaining a Foothold: Amyloid Immunotherapy in Clinical Practice
Lecanemab will soon have maintenance dosing and subcutaneous formulations available; FDA advisory committee will consider donanemab June 10.
Viral Vector Targets Transferrin Receptor to Deliver GBA1 to Brain
An adeno-associated virus that binds the transferrin receptor delivered β-glucocerebrosidase throughout the mouse brain.
Does a Rare Fibronectin Variant Protect Against APOE4?
APOE4 carriers who also have a glycine-to-glutamic-acid substitution in the extracellular matrix protein were much less likely to develop Alzheimer’s disease.
FDA Will Regulate Diagnostic Tests. Yes, Those for Alzheimer’s, Too.
Blood and other in vitro assays will need to meet the same standards as medical devices, including demonstrating diagnostic accuracy.
Do Two APOE4 Alleles Always Mean Alzheimer's?
By age 65, nearly all people who carry two copies of APOE4 harbor neuropathological or biomarker evidence of AD pathology.
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