First Success Stories From Alzheimer’s Secondary Prevention Trial
Case studies from the Dominantly Inherited Alzheimer Network trial show amyloid immunotherapy can prevent tangles and cognitive decline in some mutation carriers.
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Living Among Us: People Whose Alzheimer’s Is Already Being Prevented
On gantenerumab, some people with dominantly inherited AD mutations remain plaque- and tangle-free, and cognitively healthy, years after their expected age of onset.
Are Alzheimer’s Blood Tests Ready for Primary Care?
Plasma p-tau217/tau217, alone or with Aβ42/40, identified people with amyloid pathology more accurately than did expert clinical assessment.
Tau Tangles Linked to ‘Lonely’ Brain Waves, Forgetfulness
During non-REM sleep, waves of activity that wash slowly across the cortex help consolidate memories. Tau pathology in the frontal cortex breaks them up.
Head Injury and Parkinsonism—It’s the Tangles, Not the Lewy Bodies
In postmortem analyses of athletes who had repetitive head injuries, neurofibrillary tangles were more common than α-synuclein fibrils in the substantia nigra.
Transcriptomics Paint Astrocytes as Source of Cognitive Resilience
In people who fended off cognitive slippage despite a hefty load of plaques and tangles, astrocytes cranked up choline and polyamine synthesis.
Tau PET Misses Early AD Pathology, Primary Age-Related Tauopathy
The largest autopsy-confirmed study of tau PET to date finds that the scans cannot identify early Alzheimer’s disease or PART.
Perineuronal Pockets Prevent Spillage from Synapses
Synapses of fast-spiking interneurons nestle in holes within dense extracellular matrix. These ‘cages’ corral glutamate, so it won’t spark excitotoxicity.
Part with PILRA, Power Up Microglia?
Knocking out this immunoglobulin receptor makes microglia fit to fight. An anti-PILRA antibody does the same.
Do Tau Fibrils Form Via Droplets?
In cultured cells, mutant human tau that was forced together formed liquid droplets. When tau was missing its N-terminus, the droplets hardened into insoluble aggregates.
Do Rod-Shaped Microglia Dampen Hyperexcitability in ALS?
These microglia formed soon after overexpressing TDP-43 in a transgenic mouse. The cells pruned excitatory synapses, cooling circuits and extending lifespan.
Can Extracellular Vesicles Help Diagnose Subtypes of FTD-ALS?
Ratio of 3R/4R tau in extracellular vesicles identified people with behavioral variant FTD and PSP. Vesicle TDP43 identified bvFTD and ALS.
C1q from Microglia Meddles in Neuronal Translation
In mice, the innate immune protein slips into neurons, where it interacts with the translation machinery.
A First for Proteinopathies—Heteromeric Fibrils
In people with FTLD-TDP-43 Type C, TDP-43 and annexin A11 twist into heteromeric amyloid filaments. Could there be others?
Donanemab Approved in the U.S.
The antibody becomes the second amyloid immunotherapy to receive traditional FDA approval, joining Leqembi.
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