Confirmed: Women Accumulate Tangles Faster Than Do Men
Meta-analysis of six longitudinal studies finds that, among people who are amyloid-positive, tau PET signal rose faster in women.
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In Amyloidosis, EphA4 Goads Astrocytes to Massacre Synapses
Inhibiting this receptor calmed reactive astrocytes and curbed their consumption of synapses in the hippocampus in a mouse amyloidosis model.
Sex Differences in Blood of Alzheimer’s and Parkinson’s Patients
The largest single-cell RNA-Seq study of blood cells finds more sex-specific expression changes in PD than AD. The database is accessible online.
Fragments of Tau’s Microtubule Binding Region Mess with Synapses
In rats, antibodies to the MTBR domain and adjacent C-terminal regions spared synaptic function.
Can Autoimmunity Spark Alzheimer’s Disease?
Electronic health records show that various autoimmune disorders put people at higher risk for AD.
With Age, Macrophages Chew up the Blood-CSF Barrier
Triggered by senescent cells, macrophages spew a protease that dissolves junctions between the cells that separate CSF from blood.
By Cleaving GABA(A) Receptors, BACE1 Lifts Lid on Hyperactivity
In a mouse model of amyloidosis, the BACE1 enzyme snipped subunits of the GABA(A) receptor, squelching its inhibitory function.
Do Specialized Glycoproteins Prop Up Blood-Brain Barrier?
Thinning out glycoproteins in the brain blood vessels of young mice allowed blood to leak into the brain. Promoting glycosylation in old mice strengthened the barrier.
Parkinson’s Risk Gene Speeds Spread of α-Synuclein Pathology
In neurons, FAM171A2 opens the door to toxic fibrils. An approved cancer drug slams it shut.
Hot News: DIAN Participant Defies Presenilin 2 Mutation
The man has lots of plaques but few tangles 18 years after his expected age of onset; potential protective factors include extensive heat shock protein expression.
Could Taking Down a DNA Repair Protein Stave Off Huntington’s?
In neurons from a person with HD, knocking down MSH3 kept CAG nucleotide expansions from growing even longer.
Plasma p-Tau217 Flags Alzheimer’s Pathology in Other Disorders
The marker detected plaques and tangles with 90 percent accuracy in almost 200 autopsy-confirmed frontotemporal dementia cases.
Does COVID-19 Push People Toward Alzheimer’s? New Data Say Yes.
Plasma Aβ42/40 ratios drop in people soon after COVID-19 infection even for mild cases. Does this mean they are at higher risk for dementia?
Studying Diverse Populations May Require New Biomarkers
Amyloid and tau accumulation patterns differ in black, white, and Hispanic people.
When Tau Wanders Off, Subcortical Axon Firing Goes Mum
At HAI, scientists report that tangle accumulation in tracts from the locus coeruleus keeps neural systems from communicating with one another when neurons die.
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