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β-catenin, a protein that regulates transcription, has drawn attention in Alzheimer's research because it interacts with PS1 and PS2. It was also recently found that AD patients with the PS1 mutation have markedly reduced β-catenin...
It has long been assumed that the reason Alzheimer's patients tend to get lost is because of memory failure and confusion. But a new study appearing in tomorow’s issue of Neurology suggests that impaired processing of visual information...
Researchers in the U.K. have created conditions inside a test tube in which human prion protein can flip back and forth between normal forms and abnormal forms associated with neurodegenerative disease...
Ever since the ApoE4 allele was identified as a risk factor in late-onset Alzheimer's, researchers have speculated that ApoE interacts with β-amyloid. Several years ago, Kelly Bales and colleagues at Lilly Research Laboratories...
June Kinoshita Interviews John Hardy
The UCSD Alzheimer's Disease Cooperative Study Center is launching a $22 million study to determine whether medical intervention in individuals with mild cognitive impairment (MCI)...
In the mid-1980s, Finnish researchers reported that 68 percent of heart attack patients and 50 percent of those with coronary heart disease had antibodies to the bacterium <em>Chlamydia pneumoniae</em>, as compared to 17 percent of healthy controls...
Scientists at Sandia National Laboratories and M.I.T. have created the first computer simulation that successfully models how protein misfolding can occur...
Neurons are highly polarized cells, with certain proteins within them clearly restricted to specific regions of the plasma membrane. Yet they lack any obvious barriers to free protein diffusion...
Several years ago, Karen Hsiao and colleagues at the University of Minnesota reported that mice containing an FAD mutant form of the human amyloid precursor protein (APP) are impaired in their ability to learn...
The E4 gene variant of apolipoprotein E (ApoE) confers an increased risk of developing AD, but the mechanisms by which it does so are not understood. ApoE plays a role...
Keith A. Crutcher Interviews Rachael Neve
Brian J. Cummings Interviews Paul Coleman
Aileen Anderson Interviews Dennis Selkoe
Brian J. Cummings Interviews Hungtington Potter
