ApoE4 Makes Blood Vessels Leak, Could Kick Off Brain Damage
New evidence appearing in today’s Nature implicates the ApoE4 allele, the primary genetic risk factor for late-onset AD, as a prime culprit in damaging brain blood vessels...
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New evidence appearing in today’s Nature implicates the ApoE4 allele, the primary genetic risk factor for late-onset AD, as a prime culprit in damaging brain blood vessels...
Presenilins and calcium seem to share a close connection...
Perhaps…yes? At first blush, this is the tentative conclusion one must draw if the results of presentations yesterday on Elan's vaccine...
Using data from a longitudinal study of nearly 2000 Finnish adults, researchers have devised a simple scoring scheme to judge...
The Aβ-binding alcohol dehydrogenase (ABAD) forms a complex with Aβ in mitochondria, promoting leakage of free radicals, mitochondrial dysfunction, and cell death...
Ridding the brain of toxic amyloid may require cutting off production of Aβ peptides, but another strategy that could work is...
Apolipoprotein E4 makes people prone to Alzheimer’s disease, but scientists don't know when that risk begins to manifest...
A new mouse model has achieved a long-sought pathological prize...
Gleevec, the cancer "wonder drug" that has proven effective for gastrointestinal stromal tumors might also be useful for Alzheimer's patients, if only one could deliver it to the brain effectively...
As evidence mounts against oligomers as culprits of Aβ neurotoxicity, their only defense hinges on the possibility that they may have some normal physiological function—even a slightly neurotrophic effect—on cognition which has yet to be characterized...
As drug discovery in AD research is shifting from inhibiting the γ-secretase to inhibiting the β-secretase (BACE), interest in the entire life cycle of BACE has grown, concomitantly...
Last year, four independent research groups reported a linkage between polymorphisms in the complement factor H (CFH) gene to age-related macular degeneration...
Robert Katzman was a pioneer in bringing Alzheimer disease out of obscurity and into the forefront of medical, scientific, and social agenda of this country...
Researchers have shown that the CSF goes into the brain along very specific anatomical structures...
Topline data yesterday showed that intravenous immunoglobulin (IVIG) therapy, known as Gammagard™, failed to meet primary endpoints of slowing cognitive and functional decline...