Implicated in ARIA: Perivascular Macrophages and Microglia
These immune cells spew free radicals and inflammatory cytokines that damage blood vessels, contributing to edema and brain bleeds.
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Two New Deaths on Leqembi Highlight Need to Better Manage ARIA
These are the first deaths reported from clinical use of lecanemab. One was APOE4 homozygote; both developed severe ARIA-E and seizures.
How Presenilin Mutations Hobble γ-Secretase Predicts Onset, Progression
A study links 161 PSEN 1 mutations to age of onset and disease progression. Good news for variant calling, and for developing γ-secretase modulators.
Alzheimer's Association International Conference (AAIC) 2024
Are Alzheimer’s Blood Tests Ready for Primary Care? Living Among Us: People Whose Alzheimer’s Is Already Being Prevented First Success Stories From Alzheimer’s Secondary Prevention Trial Liraglutide Trial Was Negative Four Years Ago, Still Negative Today
Liraglutide Trial Was Negative Four Years Ago, Still Negative Today
Contrary to media stories, results of a small trial, which finished four years ago, did not demonstrate protection against cognitive decline or against brain shrinkage in people with Alzheimer’s.
First Success Stories From Alzheimer’s Secondary Prevention Trial
Case studies from the Dominantly Inherited Alzheimer Network trial show amyloid immunotherapy can prevent tangles and cognitive decline in some mutation carriers.
Living Among Us: People Whose Alzheimer’s Is Already Being Prevented
On gantenerumab, some people with dominantly inherited AD mutations remain plaque- and tangle-free, and cognitively healthy, years after their expected age of onset.
Are Alzheimer’s Blood Tests Ready for Primary Care?
Plasma p-tau217/tau217, alone or with Aβ42/40, identified people with amyloid pathology more accurately than did expert clinical assessment.
Tau Tangles Linked to ‘Lonely’ Brain Waves, Forgetfulness
During non-REM sleep, waves of activity that wash slowly across the cortex help consolidate memories. Tau pathology in the frontal cortex breaks them up.
Head Injury and Parkinsonism—It’s the Tangles, Not the Lewy Bodies
In postmortem analyses of athletes who had repetitive head injuries, neurofibrillary tangles were more common than α-synuclein fibrils in the substantia nigra.
Transcriptomics Paint Astrocytes as Source of Cognitive Resilience
In people who fended off cognitive slippage despite a hefty load of plaques and tangles, astrocytes cranked up choline and polyamine synthesis.
Tau PET Misses Early AD Pathology, Primary Age-Related Tauopathy
The largest autopsy-confirmed study of tau PET to date finds that the scans cannot identify early Alzheimer’s disease or PART.
Perineuronal Pockets Prevent Spillage from Synapses
Synapses of fast-spiking interneurons nestle in holes within dense extracellular matrix. These ‘cages’ corral glutamate, so it won’t spark excitotoxicity.
Part with PILRA, Power Up Microglia?
Knocking out this immunoglobulin receptor makes microglia fit to fight. An anti-PILRA antibody does the same.
Do Tau Fibrils Form Via Droplets?
In cultured cells, mutant human tau that was forced together formed liquid droplets. When tau was missing its N-terminus, the droplets hardened into insoluble aggregates.
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