Data Fabrication Ousted NIA Neuroscience Director Eliezer Masliah
The NIH removed Masliah from his post after an investigation found two publications with falsified data. At least 130 more papers with 500 co-authors face similar allegations.
The NIH removed Masliah from his post after an investigation found two publications with falsified data. At least 130 more papers with 500 co-authors face similar allegations.
The analysis of nearly 8,000 brains turned up three genes linked to cerebrovascular disease, and one linked to tangles.
A whole-genome sequencing study estimated that people are two to three times more likely to be affected by these mutations than predicted by epidemiology.
In mice with prion disease, microglia shifted from gobbling up misfolded protein to engulfing flagging neurons. This change coincided with symptom onset.
The adaptive nature of the interface between blood and brain led some scientists to envision it more like an actively managed border crossing, not a wall.
With genetic tinkering to their antibody transport vehicle, Denali scientists aim to temper both ARIA and anemia, while maintaining potency against Aβ.
Brain regions that have most recently evolved may be most vulnerable to FTLD.
In tauopathy mice, a peptide construct recruited protein phosphatase 1 to tau. Dephosphorylation lowered total tau, restoring synaptic density and memory.
Scientists are honing transferrin receptors to whisk bulky, anti-Aβ antibodies throughout the brain without setting off ARIA and anemia. By halving the effector function of their antibody transport vehicle, Denali researchers blunted red blood cell loss and vascular inflammation, without compromising engagement with Aβ plaques. In a related review, scientists propose rethinking the blood-brain barrier as more a bustling border crossing than a static wall. Read the two-part series.
Scientists in the Alzheimer’s and Parkinson’s research community around the world are grappling with the extent of image manipulation flagged in more than 130 papers published by Eliezer Masliah from 1997 to 2023. The irregularities range from sloppiness to falsification. After a nine-month investigation, NIH removed Masliah from his position of directing neuroscience at the NIA, but the fallout is only just beginning. The most frequent co-authors are refusing to comment, many others are revisiting their past work with the Masliah lab.
Where in the amyloid cascade does inflammation fit? Everywhere, according to a new snRNA-Seq study of more than 400 postmortem brains. The authors identified one microglial subtype that promotes plaques, another that promotes tangles, and an astrocyte subtype that contributes to cognitive decline. Intriguingly, in brains with plaques but few tangles, a different set of glial subtypes predominated. The data add to the evidence that AD has a cellular phase.
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